Droxidopa

23 interactions 50 cited references
Also sold as: Northera Northera®
About Droxidopa

Droxidopa is used to treat symptoms (dizziness, lightheadedness, or a fainting sensation [feeling that you are about to black out]) of neurogenic orthostatic hypotension (a sudden fall in blood pressure that occurs when a person assumes a standing position caused by certain nervous system conditions). Droxidopa is in a… Read the full Droxidopa drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Phenelzine Tranylcypromine Isocarboxazid Olodaterol Oral Inhalation Methylergonovine Lisdexamfetamine
3 Contraindicated 13 Major 7 Moderate
All (23) Contraindicated (3) Major (13) Moderate (7)

Contraindicated

Droxidopa Isocarboxazid Marplan An increased risk of hypertension, headache, and related symptoms Details Droxidopa Phenelzine Nardil An increased risk of hypertensive crisis Details Droxidopa Tranylcypromine Parnate Increased risk of hypertensive reaction, including intracerebral hemorrhage Details

Major

Droxidopa Amphetamine Dexedrine Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Droxidopa Dextroamphetamine Dexedrine Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Droxidopa Ergonovine Additive hypertensive effects Details Droxidopa Insulin Afrezza Reduced blood glucose lowering effect of insulin Details Droxidopa Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Droxidopa Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Droxidopa Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Droxidopa Landiolol Attenuated landiolol heart rate lowering effects Details Droxidopa Lisdexamfetamine Arynta Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Droxidopa Methylergonovine Methergine Additive hypertensive effects Details Droxidopa Midodrine Orvaten® Increased risk of hypertension Details Droxidopa Olodaterol Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details Droxidopa Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details

Moderate

Droxidopa Carbidopa Lodosyn Decreased efficacy of droxidopa Details Droxidopa Clomipramine Anafranil An increased risk of drug-drug interactions Details Droxidopa Insulin Lispro, Recombinant Admelog May decrease blood glucose lowering effect of insulin lispro Details Droxidopa Linezolid Zyvox Risk of increased blood pressure Details Droxidopa Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Droxidopa Procarbazine Risk of increased blood pressure Details Droxidopa Linezolid Injection Zyvox Risk of increased blood pressure Details

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