Felbinac and Lisinopril: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lisinopril
Felbinac
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Felbinac is an anti-inflammatory (NSAID) medicine, and lisinopril is a blood pressure medicine. When you take them together, the NSAID can make lisinopril work less well, so your blood pressure may creep up. The two can also put extra stress on your kidneys, especially if you are older, dehydrated, or already have some kidney trouble.
The good news is that this is a well-known combination that your care team can manage. Keep taking both as prescribed, stay well hydrated, and let your pharmacist or doctor know so they can check your blood pressure and kidney function and adjust things if needed.
Effect: NSAID (felbinac) may blunt the antihypertensive and natriuretic effect of the ACE inhibitor (lisinopril) and reduce renal function, with risk of acute kidney injury.
Mechanism: NSAID inhibition of renal prostaglandin synthesis reduces afferent arteriolar vasodilation; combined with ACE inhibitor effects on efferent tone, glomerular perfusion can fall. Fluid/sodium retention opposes BP control.
Evidence: Established. Onset unspecified.
- Monitor blood pressure for loss of efficacy
- Assess renal function at initiation and periodically (SCr, eGFR, potassium)
- Higher risk: elderly, volume-depleted, preexisting CKD
- Ensure adequate hydration
What happens
Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure
Interaction Deep Dive
The natriuretic and blood pressure lowering actions of ACE inhibitors or angiotensin receptor blockers (ARBs) can be reduced by NSAIDs. Their combined use may also cause worsening renal function in certain patients, with acute renal failure being a potential outcome. If these agents must be given together, evaluate whether renal function should be checked when therapy begins, watch for adequate antihypertensive response, and periodically assess renal function for indications of declining function or failure. This is particularly important in elderly patients, at the start of treatment, in those who are volume-depleted, and in individuals with existing renal impairment. Confirm that patients maintain adequate hydration1234.
Why it happens (mechanism)
Additive effects on renal function; decreased renal prostaglandin production
How to manage this interaction
This combination can be used when needed, but your care team will watch a few things:
- Blood pressure to make sure your lisinopril is still working well.
- Kidney function with blood tests, especially when starting and from time to time afterward.
- Hydration so your kidneys are protected.
Keep taking both medicines as prescribed unless told otherwise. Your doses may need to be adjusted and individualized by your care team. Tell your pharmacist or doctor if you notice much higher blood pressure readings, swelling, less urination, or if you are elderly, dehydrated, or have kidney problems, so they can monitor you more closely.
Management is individual — confirm any change with your pharmacist or prescriber.
Literature reports
4 reports — tap to read
a) A 48-year-old man with hypertension that had previously been well managed on enalapril 10 mg/day developed severe hypertension, psychosis, disorientation, and generalized anasarca four days after starting indomethacin 100 mg/day for gout 5. Raising the enalapril dose to 20 mg/day did not control the hypertension, so indomethacin was stopped. One day afterward, the patient underwent rapid diuresis along with substantial weight loss. The enalapril dose was subsequently lowered back to 10 mg/day, achieving good blood pressure control with no lingering psychosis 6.
b) In a randomized, double-blind, parallel-design multicenter study of 141 hypertensive patients, indomethacin counteracted the blood pressure lowering action of captopril. One week of combined indomethacin and captopril therapy raised 24-hour systolic blood pressure by 4.6 mmHg and diastolic by 2.7 mmHg (p less than 0.001). Across the study, ambulatory diastolic blood pressure increased in 67% of patients on captopril while receiving indomethacin 7.
c) A 59-year-old man who had been treated with lisinopril 10 mg/day for 5 years experienced worsening hypertension after rofecoxib 25/day was started for arthritic pain. Following 5 weeks, blood pressure rose from 130 to 135/80 to 85 to 168/98. Rofecoxib was stopped. Over the next 18 days blood pressure fell (average, 127/78 mmHg). Because of increased joint pain, rofecoxib was resumed at 25 mg/day. After 2 days of this therapy, blood pressure rose, and over the subsequent 2 weeks it averaged 143/89 mmHg. Lisinopril was raised to 20 mg/day, which produced an average blood pressure of 121/81 mmHg over the following 21 days 8.
d) In a double-blind, placebo-controlled, parallel-group trial of 178 hypertensive patients, celecoxib did not diminish the antihypertensive effect of lisinopril. Patients received either celecoxib 200 mg twice daily or placebo added to their usual lisinopril regimen (10 to 40 mg daily) for 4 weeks. Changes from baseline in 24-hour systolic and diastolic blood pressure (BP) were not significant. The percentage of patients whose 24-hour BP rose by at least 5, 10, 15, or 20 mmHg was also comparable between celecoxib and placebo. The placebo-subtracted changes seen in 24-hour BP (1.6/1.2 mmHg) were smaller than what has been reported for NSAIDs in patients treated with ACE inhibitors 9.
Common questions
Can I take Felbinac and Lisinopril together?
Felbinac (an NSAID) can reduce how well lisinopril controls your blood pressure and can strain your kidneys, so stay hydrated and let your care team check your blood pressure and kidney function. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Felbinac and Lisinopril interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Felbinac and Lisinopril interaction managed?
This combination can be used when needed, but your care team will watch a few things: Blood pressure to make sure your lisinopril is still working well. Kidney function with blood tests, especially when starting and from time to time afterward. Hydration so your kidneys are protected. Keep taking both medicines as prescribed unless told otherwise. Your doses may need to be adjusted and individuali… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Felbinac or Lisinopril need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (9)
- Product Information: Dynastat intravenous injection, intramuscular injection, parecoxib sodium intravenous injection, intramuscular injection. Pfizer Australia Pty Ltd (per Australian Register of Therapeutic Goods), West Ryde, Australia, 2017. DailyMed
- Product Information: SPRIX(R) nasal spray, ketorolac tromethamine nasal spray. Egalet US Inc. (per FDA), Wayne, PA, 2016. DailyMed
- Product Information: CALDOLOR(R) intravenous injection, ibuprofen intravenous injection. Cumberland Pharmaceuticals Inc. (per FDA), Nashville, TN, 2016. DailyMed
- Product Information: meloxicam oral tablets, meloxicam oral tablets. Apotex Corp. (per DailyMed), Weston, FL, 2016. DailyMed
- Ahmad S: Indomethacin-enalapril interaction: an alert (letter). South Med J 1991; 84:411-412. PubMed
- Morgan T, Anderson A, & Bertram D: Effect of indomethacin on blood pressure in elderly people with essential hypertension well controlled on amlodipine or enalapril. Am J Hypertens 2000; 13:1161-1167. PubMed
- Conlin P, Moore T, Swartz S, et al: Effect of indomethacin on blood pressure lowering by captopril and losartan in hypertensive patients. Hypertension 2000; 36:461-465. PubMed
- Brown C: Effect of rofecoxib on the antihypertensive activity of lisinopril (letter). Ann Pharmacother 2000; 34:1486. PubMed
- White W, Kent J, Taylor A, et al: Effects of celecoxib on ambulatory blood pressure in hypertensive patients on ACE inhibitors. Hypertension 2002; 39:929-934. PubMed
Keep reading about Lisinopril
Keep reading about Felbinac
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