Fluvastatin and Clarithromycin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Clarithromycin
Fluvastatin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased fluvastatin exposure and an increased risk of fluvastatin-related adverse events (increased risk of fluvastatin toxicities, myopathy and rhabdomyolysis)
Interaction Deep Dive
Concomitant use of clarithromycin and fluvastatin may increase exposure of fluvastatin, thereby increasing the risk of fluvastatin-related toxicities. If concomitant use cannot be avoided use the lowest registered dose1.
Why it happens (mechanism)
Unknown
Common questions
Can I take Fluvastatin and Clarithromycin together?
Increased fluvastatin exposure and an increased risk of fluvastatin-related adverse events (increased risk of fluvastatin toxicities, myopathy and rhabdomyolysis) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Fluvastatin and Clarithromycin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Fluvastatin or Clarithromycin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VOQUEZNA(R) TRIPLE PAK(R) oral kit, vonoprazan oral tablets, amoxicillin oral capsules, clarithromycin oral tablets kit. Phathom Pharmaceuticals (per FDA), Buffalo Grove, IL, 2024. DailyMed
Keep reading about Clarithromycin
Keep reading about Fluvastatin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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