Fluvoxamine and Glimepiride: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Fluvoxamine
No brand names on recordGlimepiride
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increase in plasma concentrations of glimepiride
Interaction Deep Dive
Caution is advised when fluvoxamine is coadministered with glimepiride. An increase in plasma concentrations of glimepiride has been documented in healthy patients when used concomitantly with fluvoxamine without a significant effect on blood glucose concentrations1.
Why it happens (mechanism)
Inhibition of the metabolism of glimepiride through the cytochrome P450 2C9 enzyme
Literature reports
1 report — tap to read
a) Plasma concentrations of glimepiride were moderately increased when used concomitantly with fluvoxamine. A double-blind, randomized, crossover study with three phases including a 4-week washout period between the phases was conducted in twelve healthy volunteers. The aim of the study is to investigate the effects of fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride. Subjects received fluvoxamine 100 mg or placebo orally once daily for 4 days. On day 4, a single oral dose of 0.5 mg of glimepiride was administered after the patients fasted overnight. Meals were served 15 minutes after, 3 hours after, and 7 hours after glimepiride administration. For the fluvoxamine phase, the peak concentration (Cmax) was 143% (p less than 0.05) of the respective placebo value, and the half-life was increased from 2 to 2.3 hours (p less than 0.01). The increase in the area under the concentration-time curve (AUC) was not significant, and differences in blood glucose levels were not statistically significant 1.
Common questions
Can I take Fluvoxamine and Glimepiride together?
An increase in plasma concentrations of glimepiride Always confirm with your pharmacist or prescriber before making any change.
How serious is the Fluvoxamine and Glimepiride interaction?
It is rated minor. Usually limited clinical impact.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Fluvoxamine or Glimepiride need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Niemi M, Backman JT, Neuvonen M, et al: Effects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride. Clin Pharmacol Ther 2001; 69(4):194-200. PubMed
Keep reading about Fluvoxamine
Keep reading about Glimepiride
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