Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Morphine An increased risk of seizures Details Hydroxychloroquine Moxifloxacin Avelox An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Nadifloxacin An increased risk of seizures Details Hydroxychloroquine Nafarelin Increased risk of QT interval prolongation Details Hydroxychloroquine Nafcillin An increased risk of seizures Details Hydroxychloroquine Nalbuphine An increased risk of seizures Details Hydroxychloroquine Nalidixic Acid An increased risk of seizures Details Hydroxychloroquine Nateglinide Starlix® Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Nefazodone An increased risk of seizures Details Hydroxychloroquine Nelfinavir Viracept Increased risk of QT interval prolongation Details Hydroxychloroquine Neostigmine An increased risk of seizures Details Hydroxychloroquine Niaprazine An increased risk of seizures Details Hydroxychloroquine Nilotinib Increased risk of QT interval prolongation Details Hydroxychloroquine Norfloxacin An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Octreotide Bynfezia Increased risk of QT interval prolongation Details Hydroxychloroquine Ofloxacin Floxin® An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Olanzapine An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Olodaterol Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Hydroxychloroquine Olopatadine Pataday An increased risk of seizures Details Hydroxychloroquine Ondansetron Increased risk of QT interval prolongation Details Hydroxychloroquine Opipramol An increased risk of seizures Details Hydroxychloroquine Osilodrostat Isturisa Increased risk of QT interval prolongation Details Hydroxychloroquine Osimertinib Tagrisso Increased risk of QT interval prolongation Details Hydroxychloroquine Oxacillin An increased risk of seizures Details Hydroxychloroquine Oxaliplatin Increased risk of QT interval prolongation Details Hydroxychloroquine Oxatomide An increased risk of seizures Details Hydroxychloroquine Oxcarbazepine Oxtellar Impaired antiepileptic activity Details Hydroxychloroquine Oxybutynin Ditropan An increased risk of seizures Details Hydroxychloroquine Oxymorphone An increased risk of seizures Details Hydroxychloroquine Ozanimod Additive effects on heart rate Details Hydroxychloroquine Pacritinib Vonjo® An increased risk of QT interval prolongation Details Hydroxychloroquine Paliperidone Erzofri Increased risk of QT interval prolongation Details Hydroxychloroquine Panobinostat Farydak Increased risk of QT interval prolongation Details Hydroxychloroquine Papaverine Pavacot® Increased risk of QT interval prolongation Details Hydroxychloroquine Paroxetine Paxil Increased risk of QT interval prolongation Details Hydroxychloroquine Pasireotide Signifor Increased risk of QT interval prolongation Details Hydroxychloroquine Pazopanib Votrient Increased risk of QT interval prolongation Details Hydroxychloroquine Pazufloxacin An increased risk of seizures Details Hydroxychloroquine Pefloxacin An increased risk of seizures Details Hydroxychloroquine Penicillin G An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.