Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Penicillin V An increased risk of seizures Details Hydroxychloroquine Pentamidine NebuPent Increased risk of QT interval prolongation Details Hydroxychloroquine Pentazocine An increased risk of seizures Details Hydroxychloroquine Pentobarbital Sodium Impaired antiepileptic activity Details Hydroxychloroquine Perampanel FYCOMPA Impaired antiepileptic activity Details Hydroxychloroquine Perazine An increased risk of seizures Details Hydroxychloroquine Periciazine An increased risk of seizures Details Hydroxychloroquine Perphenazine Increased risk of QT interval prolongation Details Hydroxychloroquine Phenindamine An increased risk of seizures Details Hydroxychloroquine Pheniramine An increased risk of seizures Details Hydroxychloroquine Phenobarbital Fidoquel Impaired antiepileptic activity and an increased risk of QT interval prolongation Details Hydroxychloroquine Phenobarbital Sodium Impaired antiepileptic activity and an increased risk of QT interval prolongation Details Hydroxychloroquine Phenylpropanolamine An increased risk of seizures Details Hydroxychloroquine Phenyltoloxamine An increased risk of seizures Details Hydroxychloroquine Phenytoin Dilantin Impaired antiepileptic activity Details Hydroxychloroquine Phenytoin Sodium Impaired antiepileptic activity Details Hydroxychloroquine Phenytoin Sodium, Extended Impaired antiepileptic activity Details Hydroxychloroquine Physostigmine An increased risk of seizures Details Hydroxychloroquine Pimavanserin Nuplazid An increased risk of QT interval prolongation Details Hydroxychloroquine Pinaverium An increased risk of seizures Details Hydroxychloroquine Pioglitazone Actos Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Pipamperone An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Piperacillin An increased risk of seizures Details Hydroxychloroquine Pipotiazine An increased risk of seizures Details Hydroxychloroquine Pirenzepine An increased risk of seizures Details Hydroxychloroquine Pitolisant Wakix Increased risk of QT interval prolongation Details Hydroxychloroquine Pivampicillin An increased risk of seizures Details Hydroxychloroquine Pivmecillinam An increased risk of seizures Details Hydroxychloroquine Pizotyline An increased risk of seizures Details Hydroxychloroquine Polyestradiol Phosphate An increased risk of seizures Details Hydroxychloroquine Ponesimod Ponvory An increased risk of QT interval prolongation Details Hydroxychloroquine Posaconazole Noxafil Increased risk of QT interval prolongation Details Hydroxychloroquine Pramlintide Symlin Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Pregabalin Bonqat Impaired antiepileptic activity Details Hydroxychloroquine Primidone Mysoline Impaired antiepileptic activity and an increased risk of QT interval prolongation Details Hydroxychloroquine Probucol Increased risk of QT interval prolongation Details Hydroxychloroquine Procainamide Procan® Increased risk of QT interval prolongation Details Hydroxychloroquine Procaine An increased risk of seizures Details Hydroxychloroquine Prochlorperazine An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Proguanil An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.