Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Siponimod Mayzent An increased risk of QT interval prolongation Details Hydroxychloroquine Sitagliptin Brynovin Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Sodium Bicarbonate Alka-Seltzer® Heartburn Reduced hydroxychloroquine exposure Details Hydroxychloroquine Sodium Phosphate OsmoPrep Increased risk of QT interval prolongation Details Hydroxychloroquine Sodium Phosphate, Dibasic Increased risk of QT interval prolongation Details Hydroxychloroquine Sodium Phosphate, Monobasic Increased risk of QT interval prolongation Details Hydroxychloroquine Solifenacin Vesicare An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Sorafenib Nexavar Increased risk of QT interval prolongation Details Hydroxychloroquine Sotalol Betapace An increased risk of QT interval prolongation Details Hydroxychloroquine Stiripentol Diacomit Impaired antiepileptic activity Details Hydroxychloroquine Sufentanil Dsuvia An increased risk of seizures Details Hydroxychloroquine Sulbenicillin An increased risk of seizures Details Hydroxychloroquine Sulpiride An increased risk of QT interval prolongation Details Hydroxychloroquine Sultamicillin An increased risk of seizures Details Hydroxychloroquine Sultopride Increased risk of QT interval prolongation Details Hydroxychloroquine Sumatriptan Imitrex An increased risk of seizures Details Hydroxychloroquine Sunitinib Sutent Increased risk of QT interval prolongation Details Hydroxychloroquine Tacrine An increased risk of seizures Details Hydroxychloroquine Tacrolimus Astagraf Increased risk of QT interval prolongation Details Hydroxychloroquine Taletrectinib Ibtrozi Increased risk of QT interval prolongation and torsade de pointes Details Hydroxychloroquine Tamoxifen Nolvadex® Increased risk of retinal toxicity and increased risk of QT-interval prolongation Details Hydroxychloroquine Tapentadol Nucynta An increased risk of seizures Details Hydroxychloroquine Telaprevir Increased risk of QT interval prolongation Details Hydroxychloroquine Telavancin Vibativ Increased risk of QT interval prolongation Details Hydroxychloroquine Telithromycin Increased risk of QT interval prolongation Details Hydroxychloroquine Temocillin An increased risk of seizures Details Hydroxychloroquine Tetrabenazine Xenazine Increased risk of QT interval prolongation Details Hydroxychloroquine Theophylline Accurbron® An increased risk of seizures Details Hydroxychloroquine Thiethylperazine An increased risk of seizures Details Hydroxychloroquine Thiopropazate An increased risk of seizures Details Hydroxychloroquine Thioproperazine An increased risk of seizures Details Hydroxychloroquine Thiothixene An increased risk of seizures Details Hydroxychloroquine Thonzylamine An increased risk of seizures Details Hydroxychloroquine Tiagabine Hydrochloride Impaired antiepileptic activity Details Hydroxychloroquine Tianeptine An increased risk of seizures Details Hydroxychloroquine Tibolone An increased risk of seizures Details Hydroxychloroquine Ticarcillin An increased risk of seizures Details Hydroxychloroquine Timiperone An increased risk of seizures Details Hydroxychloroquine Tolazamide Tolinase® Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Tolbutamide Orinase® Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.