Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Tolterodine Detrol An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Topiramate Eprontia Impaired antiepileptic activity Details Hydroxychloroquine Toremifene Fareston Increased risk of QT interval prolongation Details Hydroxychloroquine Tramadol ConZip Increased traMADol exposure, reduced exposure of the active metabolite and an increased risk of seizure Details Hydroxychloroquine Trazodone Raldesy Increased risk of QT interval prolongation Details Hydroxychloroquine Triclabendazole Egaten An increased risk of QT interval prolongation Details Hydroxychloroquine Triflupromazine An increased risk of seizures Details Hydroxychloroquine Trimeprazine An increased risk of seizures Details Hydroxychloroquine Trimipramine Increased risk of QT interval prolongation Details Hydroxychloroquine Tripelennamine An increased risk of seizures Details Hydroxychloroquine Triprolidine An increased risk of seizures Details Hydroxychloroquine Triptorelin Increased risk of QT interval prolongation Details Hydroxychloroquine Tropicamide Mydriacyl An increased risk of seizures Details Hydroxychloroquine Trospium An increased risk of seizures Details Hydroxychloroquine Umeclidinium An increased risk of seizures Details Hydroxychloroquine Valethamate An increased risk of seizures Details Hydroxychloroquine Valproate Sodium Impaired antiepileptic activity Details Hydroxychloroquine Valproic Acid Depakene® Impaired antiepileptic activity Details Hydroxychloroquine Vandetanib Caprelsa Increased risk of QT interval prolongation Details Hydroxychloroquine Vardenafil Levitra Increased risk of QT interval prolongation Details Hydroxychloroquine Vemurafenib Zelboraf Increased risk of QT interval prolongation Details Hydroxychloroquine Venlafaxine Increased risk of QT interval prolongation Details Hydroxychloroquine Vepdegestrant Veppanu An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Hydroxychloroquine Vigabatrin Sabril Impaired antiepileptic activity Details Hydroxychloroquine Vilanterol Increased risk of QT interval prolongation Details Hydroxychloroquine Vinflunine Increased risk of QT interval prolongation Details Hydroxychloroquine Voclosporin Lupkynis An increased risk of QT interval prolongation Details Hydroxychloroquine Voglibose Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Voriconazole Vfend Increased risk of QT interval prolongation Details Hydroxychloroquine Vorinostat Zolinza Increased risk of QT interval prolongation Details Hydroxychloroquine Zidovudine Retrovir An increased risk of seizures Details Hydroxychloroquine Ziftomenib Komzifti An increased risk of QT interval prolongation and torsade de pointes Details Hydroxychloroquine Zonisamide Zonegran Impaired antiepileptic activity Details Hydroxychloroquine Zotepine Increased risk of QT interval prolongation Details Hydroxychloroquine Zuclopenthixol An increased risk of QT interval prolongation Details Hydroxychloroquine Ifosfamide Injection Ifex An increased risk of seizures Details Hydroxychloroquine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Hydroxychloroquine Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Insulin Detemir (Rdna Origin) Injection Levemir Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Insulin Glulisine (Rdna Origin) Injection Apidra Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.