Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Hydroxychloroquine Ketotifen Ophthalmic Alaway An increased risk of seizures Details Hydroxychloroquine Lacosamide Injection Motpoly Impaired antiepileptic activity Details Hydroxychloroquine Levetiracetam Injection Elepsia Impaired antiepileptic activity Details Hydroxychloroquine Levofloxacin Injection Levaquin An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Liraglutide Injection Saxenda Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Lithium Carbonate Lithobid An increased risk of seizures Details Hydroxychloroquine Lixisenatide Injection Adlyxin® Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Hydroxychloroquine Methylphenidate Transdermal Patch Daytrana An increased risk of seizures Details Hydroxychloroquine Metronidazole Injection Flagyl An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Metronidazole Topical MetroCream® An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Metronidazole Vaginal MetroGel® Vaginal An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Midazolam Nasal Spray Nayzilam Impaired antiepileptic activity Details Hydroxychloroquine Midazolam Injection Nayzilam Impaired antiepileptic activity Details Hydroxychloroquine Morphine Injection Astramorph® PF An increased risk of seizures Details Hydroxychloroquine Moxifloxacin Injection Avelox An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Moxifloxacin Ophthalmic Moxeza® An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Nafarelin Nasal Spray Synarel Increased risk of QT interval prolongation Details Hydroxychloroquine Nafcillin Injection Unipen® Injection An increased risk of seizures Details Hydroxychloroquine Nalbuphine Injection Nubain® An increased risk of seizures Details Hydroxychloroquine Neostigmine Methylsulfate Bloxiverz An increased risk of seizures Details Hydroxychloroquine Octreotide Injection Bynfezia Increased risk of QT interval prolongation Details Hydroxychloroquine Ofloxacin Ophthalmic Ocuflox An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Ofloxacin Otic Floxin® Otic An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Hydroxychloroquine Olopatadine Nasal Spray PATANASE An increased risk of seizures Details Hydroxychloroquine Oxaliplatin Injection Eloxatin® Increased risk of QT interval prolongation Details Hydroxychloroquine Penicillin V Potassium Beepen-VK® An increased risk of seizures Details

Moderate

Hydroxychloroquine Lanthanum Carbonate Fosrenol Reduced bioavailability of antimalarials Details Hydroxychloroquine Lanthanum Fosrenol® Reduced bioavailability of antimalarials Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.