Isosorbide Dinitrate

Name: Isosorbide Dinitrate Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

7 interactions 284 cited references

Also sold as: Isochron IsoDitrate Isordil

Read the full Isosorbide Dinitrate drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Avanafil Riociguat Sildenafil Tadalafil Vardenafil Articaine

5 Contraindicated 2 Major

All (7) Contraindicated (5) Major (2)

Contraindicated

Isosorbide Dinitrate Avanafil Stendra Potentiation of hypotensive effects Details Isosorbide Dinitrate Riociguat Adempas Increased risk of hypotension Details Isosorbide Dinitrate Sildenafil Liqrev Potentiation of hypotensive effects Details Isosorbide Dinitrate Tadalafil Adcirca Increased hypotensive effects of nitrates Details Isosorbide Dinitrate Vardenafil Levitra Potentiation of hypotensive effects Details

Major

Isosorbide Dinitrate Articaine An increased risk of methemoglobinemia Details Isosorbide Dinitrate Lidocaine Akten An increased risk of methemoglobinemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.