Levodopa

26 interactions 2 explained in plain English
Also sold as: Inbrija
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Metoclopramide Nasal Spray Nalbuphine Injection Hydromorphone Injection Cetirizine Injection Asenapine Transdermal Patch
1 Contraindicated 24 Major 1 Minor
All (26) Contraindicated (1) Major (24) Minor (1)

Contraindicated

Levodopa Linezolid Injection Zyvox Hypertensive crisis Details

Major

Levodopa Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of CNS depression Details Levodopa Buprenorphine Belbuca Explained An increased risk of CNS depression Details Levodopa Amisulpride Injection Barhemsys Decreased efficacy of both agents Details Levodopa Aripiprazole Injection Abilify An increased risk of CNS depression Details Levodopa Asenapine Transdermal Patch Secuado An increased risk of CNS depression Details Levodopa Butorphanol Injection Butorphic An increased risk of CNS depression Details Levodopa Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression Details Levodopa Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Levodopa Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Levodopa Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Levodopa Diazepam Rectal Diastat An increased risk of CNS depression Details Levodopa Diphenhydramine Injection Banophen An increased risk of CNS depression Details Levodopa Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression Details Levodopa Esketamine Nasal Spray Spravato An increased risk of CNS depression Details Levodopa Fentanyl Transdermal Patch Duragesic® An increased risk of CNS depression Details Levodopa Fexofenadine Allegra Reduced efficacy of levodopa and an increased risk of exacerbating psychosis (or symptoms of Parkinson's disease: delusion, confus... Details Levodopa Hydromorphone Injection Dilaudid An increased risk of CNS depression Details Levodopa Hydromorphone Rectal available generically An increased risk of CNS depression Details Levodopa Metoclopramide Injection Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details Levodopa Metoclopramide Nasal Spray Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details Levodopa Midazolam Nasal Spray Nayzilam An increased risk of CNS depression Details Levodopa Midazolam Injection Nayzilam An increased risk of CNS depression Details Levodopa Morphine Injection Astramorph® PF An increased risk of CNS depression Details Levodopa Nalbuphine Injection Nubain® An increased risk of CNS depression Details

Minor

Levodopa Methyldopa Aldomet® Altered response to levodopa and/or enhanced hypotensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.