Lisinopril and Lanthanum Carbonate: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lisinopril
Lanthanum Carbonate
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Here's what's going on. Lisinopril is a blood pressure medicine, and lanthanum carbonate (Fosrenol) is a phosphate binder often used if your kidneys need help. When these two sit in your stomach at the same time, the lanthanum can grab onto the lisinopril and keep some of it from getting absorbed. That could make your blood pressure medicine work a little less well.
The good news: this is easy to work around. Spacing the two medicines apart usually solves it. This concern is based mostly on how the drugs behave in theory, not strong human studies, so don't worry. Just check with your pharmacist or doctor about the best timing.
Effect: Reduced oral bioavailability of lisinopril, potentially blunting its antihypertensive effect.
Mechanism: Lisinopril can bind to cationic lanthanum in the GI tract, forming a poorly absorbed complex (chelation-type interaction). Lisinopril is an active drug, not a prodrug, so reduced absorption directly reduces effect.
- Direction: Decreased lisinopril exposure / effect
- Onset: Unspecified
- Evidence: Theoretical
- Management: Separate dosing; give lisinopril at least 2 hours apart from lanthanum. Monitor blood pressure response; individualize dosing if control appears inadequate.
What happens
Reduced bioavailability of ACE inhibitors
Interaction Deep Dive
When lanthanum is given together with ACE inhibitors, exercise caution because the bioavailability of the ACE inhibitor may be diminished. Should the two agents need to be used together, refrain from giving ACE inhibitors within a 2 hour window of lanthanum administration1.
Why it happens (mechanism)
Binding of ACE inhibitors to cationic groups of lanthanum
How to manage this interaction
This is manageable with simple timing. Keep taking both medicines as prescribed unless your care team tells you otherwise.
- If you take both, avoid taking lisinopril within 2 hours of your lanthanum dose. Separating them lets the lisinopril absorb properly.
- Ask your pharmacist to help you set up a daily schedule that keeps them apart.
- Your team may check your blood pressure to confirm the lisinopril is still working, and they can adjust and individualize your dose if needed.
Bring up any change in blood pressure readings with your pharmacist or prescriber.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Lisinopril and Lanthanum Carbonate together?
Lanthanum can reduce how much lisinopril your body absorbs, so take your lisinopril at least 2 hours apart from lanthanum and keep an eye on your blood pressure with your care team. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lisinopril and Lanthanum Carbonate interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Lisinopril and Lanthanum Carbonate interaction managed?
This is manageable with simple timing. Keep taking both medicines as prescribed unless your care team tells you otherwise. If you take both, avoid taking lisinopril within 2 hours of your lanthanum dose. Separating them lets the lisinopril absorb properly. Ask your pharmacist to help you set up a daily schedule that keeps them apart. Your team may check your blood pressure to confirm the lisinopri… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Lisinopril or Lanthanum Carbonate need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: FOSRENOL(R) oral chewable tablets oral powder, lanthanum carbonate oral chewable tablets oral powder. Shire US Inc. (per FDA), Wayne, IN, 2014. DailyMed
Keep reading about Lisinopril
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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