Lorcaserin

21 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Lithium Carbonate Nalbuphine Injection Hydromorphone Injection Brexpiprazole Palonosetron Injection
19 Major 2 Moderate
All (21) Major (19) Moderate (2)

Major

Lorcaserin Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Lorcaserin Amitriptyline Elavil Explained Increased amitriptyline plasma concentrations; increased risk of serotonin syndrome Details Lorcaserin Sertraline Explained Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Lorcaserin Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Lorcaserin Brexpiprazole Rexulti Increased brexpiprazole exposure Details Lorcaserin Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Lorcaserin Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Lorcaserin Dolasetron Anzemet Increased risk of serotonin syndrome Details Lorcaserin Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Lorcaserin Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Lorcaserin Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Lorcaserin Granisetron Injection Granisol Increased risk of serotonin syndrome Details Lorcaserin Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Lorcaserin Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Lorcaserin Linezolid Injection Zyvox Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Lorcaserin Lithium Carbonate Lithobid Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Lorcaserin Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Lorcaserin Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Lorcaserin Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Lorcaserin Flecainide Tambocor® Increased flecainide plasma concentrations Details Lorcaserin Mexiletine Mexitil® Increased mexiletine plasma concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.