Memantine

24 interactions 86 cited references
Also sold as: Namenda Namenda XR® Namenda® Namenda® Titration Pak Namzaric®(as a combination product containing Donepezil, Memantine)
About Memantine

Memantine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain. M… Read the full Memantine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dextromethorphan Dorzolamide Ketamine Methotrexate Injection Amantadine Brinzolamide
16 Major 8 Moderate
All (24) Major (16) Moderate (8)

Major

Memantine Acetazolamide Diamox® Sequels® Reduced clearance of memantine Details Memantine Azathioprine Azasan An increased risk of hepatotoxicity Details Memantine Brinzolamide Ophthalmic Azopt Reduced clearance of memantine Details Memantine Dorzolamide Ophthalmic Trusopt® Ocumeter® Plus Reduced clearance of memantine Details Memantine Amantadine Increased adverse events of N-methyl-D-aspartate antagonists Details Memantine Brinzolamide Reduced clearance of memantine Details Memantine Bupropion Aplenzin Reduced renal clearance of OCT2 substrates Details Memantine Dextromethorphan Delsym Increased adverse events of N-methyl-D-aspartate antagonists Details Memantine Dorzolamide Reduced clearance of memantine Details Memantine Ketamine Increased adverse events of N-methyl-D-aspartate antagonists Details Memantine Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Memantine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Memantine Methazolamide Neptazane® Reduced clearance of memantine Details Memantine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Memantine Sodium Bicarbonate Alka-Seltzer® Heartburn Reduced renal clearance of memantine Details Memantine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Memantine Cimetidine Tagamet Altered plasma levels of memantine and cimetidine Details Memantine Hydrochlorothiazide Inzirqo Altered plasma levels of memantine and hydrochlorothiazide Details Memantine Nicotine Altered plasma levels of memantine and nicotine Details Memantine Quinidine Cardioquin® Altered plasma levels of memantine and quinidine Details Memantine Ranitidine Altered plasma levels of memantine and ranitidine Details Memantine Trimethoprim Primsol Increased memantine exposure Details Memantine Nicotine Nasal Spray Nicotrol Altered plasma levels of memantine and nicotine Details Memantine Nicotine Transdermal Patch Commit® lozenges Altered plasma levels of memantine and nicotine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.