Memantine
24 interactions 86 cited referencesMemantine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain. M… Read the full Memantine drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Memantine Acetazolamide Diamox® Sequels® Reduced clearance of memantine Details Memantine Azathioprine Azasan An increased risk of hepatotoxicity Details Memantine Brinzolamide Ophthalmic Azopt Reduced clearance of memantine Details Memantine Dorzolamide Ophthalmic Trusopt® Ocumeter® Plus Reduced clearance of memantine Details Memantine Amantadine Increased adverse events of N-methyl-D-aspartate antagonists Details Memantine Brinzolamide Reduced clearance of memantine Details Memantine Bupropion Aplenzin Reduced renal clearance of OCT2 substrates Details Memantine Dextromethorphan Delsym Increased adverse events of N-methyl-D-aspartate antagonists Details Memantine Dorzolamide Reduced clearance of memantine Details Memantine Ketamine Increased adverse events of N-methyl-D-aspartate antagonists Details Memantine Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Memantine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Memantine Methazolamide Neptazane® Reduced clearance of memantine Details Memantine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Memantine Sodium Bicarbonate Alka-Seltzer® Heartburn Reduced renal clearance of memantine Details Memantine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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