Memantine

Name: Memantine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

24 interactions 86 cited references

Also sold as: Namenda Namenda XR® Namenda® Namenda® Titration Pak Namzaric®(as a combination product containing Donepezil, Memantine)

About Memantine

Memantine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain. M… Read the full Memantine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dextromethorphan Dorzolamide Ketamine Methotrexate Injection Amantadine Brinzolamide

16 Major 8 Moderate

All (24) Major (16) Moderate (8)

Moderate

Memantine Cimetidine Tagamet Altered plasma levels of memantine and cimetidine Details Memantine Hydrochlorothiazide Inzirqo Altered plasma levels of memantine and hydrochlorothiazide Details Memantine Nicotine Altered plasma levels of memantine and nicotine Details Memantine Quinidine Cardioquin® Altered plasma levels of memantine and quinidine Details Memantine Ranitidine Altered plasma levels of memantine and ranitidine Details Memantine Trimethoprim Primsol Increased memantine exposure Details Memantine Nicotine Nasal Spray Nicotrol Altered plasma levels of memantine and nicotine Details Memantine Nicotine Transdermal Patch Commit® lozenges Altered plasma levels of memantine and nicotine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.