Mephobarbital
31 interactions 3 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Acetaminophen And Codeine
Nalbuphine Injection
Hydromorphone Injection
Metoclopramide Nasal Spray
Levodopa Oral Inhalation
Cetirizine Injection
Major
Mephobarbital Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Mephobarbital Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Mephobarbital Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Mephobarbital Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Mephobarbital Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Mephobarbital Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Mephobarbital Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Mephobarbital Diazepam Nasal Spray Valtoco An increased risk of CNS and respiratory depression Details Mephobarbital Diazepam Rectal Diastat An increased risk of CNS and respiratory depression Details Mephobarbital Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Mephobarbital Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Mephobarbital Esketamine Nasal Spray Spravato Increased risk of sedation Details Mephobarbital Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Mephobarbital Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Mephobarbital Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Mephobarbital Lacosamide Injection Motpoly An increased risk of CNS depression Details Mephobarbital Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Mephobarbital Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Mephobarbital Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Mephobarbital Metoclopramide Injection Gimoti Increased risk of CNS depression Details Mephobarbital Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Mephobarbital Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Mephobarbital Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Mephobarbital Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Mephobarbital Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression DetailsModerate
Mephobarbital Capsaicin Arthricare for Women Moisturizing Increased or decreased effectiveness of barbiturates Details Mephobarbital Capsaicin Topical Aspercreme Warming® Increased or decreased effectiveness of barbiturates Details Mephobarbital Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased or decreased effectiveness of barbiturates Details Mephobarbital Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Mephobarbital Folic Acid Folacin Reduced folic acid exposure, reduced barbiturates exposure and reduced efficacy of barbiturate Details Mephobarbital Ospemifene Osphena Decreased ospemifene exposure and efficacy DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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