Mephobarbital

31 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Mephobarbital Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Mephobarbital Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Mephobarbital Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Mephobarbital Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Mephobarbital Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Mephobarbital Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Mephobarbital Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Mephobarbital Diazepam Nasal Spray Valtoco An increased risk of CNS and respiratory depression Details Mephobarbital Diazepam Rectal Diastat An increased risk of CNS and respiratory depression Details Mephobarbital Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Mephobarbital Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Mephobarbital Esketamine Nasal Spray Spravato Increased risk of sedation Details Mephobarbital Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Mephobarbital Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Mephobarbital Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Mephobarbital Lacosamide Injection Motpoly An increased risk of CNS depression Details Mephobarbital Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Mephobarbital Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Mephobarbital Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Mephobarbital Metoclopramide Injection Gimoti Increased risk of CNS depression Details Mephobarbital Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Mephobarbital Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Mephobarbital Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Mephobarbital Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Mephobarbital Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.