Nifedipine and Vincristine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Nifedipine
Vincristine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of vinCRIStine toxicity (neuropathy, delirium, seizures)
Interaction Deep Dive
Analysis of pharmacokinetic data involving patients who received NIFEdipine before and during vinCRIStine therapy compared to patients who only received vinCRIStine showed that NIFEdipine increased the vinCRIStine half-life and the area under the concentration-time curve1. One possible mechanism would be decreased vinCRIStine metabolism due to inhibition of outward transport from intracellular sites exerted by NIFEdipine 2.
Why it happens (mechanism)
Altered metabolism
Literature reports
1 report — tap to read
a) Twenty-six patients with solid tumors and normal renal and liver function were administered vinCRIStine 2 mg. Twelve subjects were given oral NIFEdipine 10 mg three times daily for three days before and seven days after vinCRIStine administration. The control group consisted of the remaining 14 patients who received only vincristine. The NIFEdipine-treated patients demonstrated reduced total plasma clearance of vinCRIStine and reduced 7-day urinary excretion of vinCRIStine 1.
Common questions
Can I take Nifedipine and Vincristine together?
An increased risk of vinCRIStine toxicity (neuropathy, delirium, seizures) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Nifedipine and Vincristine interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Nifedipine or Vincristine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
Keep reading about Nifedipine
Keep reading about Vincristine
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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