Vincristine

Name: Vincristine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

12 interactions 1 explained in plain English

Also sold as: Marqibo Vincasar

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abametapir Azathioprine Asparaginase Erwinia Chrysanthemi Injection Ketoconazole Topical Letermovir Injection Mercaptopurine

8 Major 4 Moderate

All (12) Major (8) Moderate (4)

Major

Vincristine Abametapir Explained Increased exposure of CYP3A4 substrate Details Vincristine Azathioprine Azasan An increased risk of hepatotoxicity Details Vincristine Asparaginase Erwinia Chrysanthemi Injection Erwinaze An increased risk of toxicity and anaphylaxis Details Vincristine Ketoconazole Topical Extina® Foam Increased vinCRIStine exposure Details Vincristine Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Vincristine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Vincristine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Vincristine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Vincristine Cyclosporine Injection Atopica Increased vinCRIStine plasma concentrations and risk of adverse reactions Details Vincristine Cyclosporine Ophthalmic Cequa Increased vinCRIStine plasma concentrations and risk of adverse reactions Details Vincristine Digoxin Cardoxin® Decreased digoxin effectiveness Details Vincristine Nifedipine Adalat® An increased risk of vinCRIStine toxicity (neuropathy, delirium, seizures) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.