Omeprazole

Name: Omeprazole Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

142 interactions 106 explained in plain English 955 cited references

Also sold as: Gastrobim Prilosec Prilosec® Prilosec® OTC Primeguard Talicia (as a combination product containing Amoxicillin, Omeprazole, Rifabutin) UlcerGard

About Omeprazole

A proton-pump inhibitor used to treat acid reflux, heartburn, and stomach ulcers. Read the full Omeprazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Rilpivirine Acalabrutinib Amphetamine Octreotide Injection Diazepam Rectal

2 Contraindicated 114 Major 23 Moderate 3 Minor

All (142) Contraindicated (2) Major (114) Moderate (23) Minor (3)

Contraindicated

Omeprazole Ensitrelvir Explained Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Omeprazole Rilpivirine Edurant Explained Reduced oral rilpivirine exposure, reduced efficacy of rilpivirine and an increased loss of virologic response Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.