Omeprazole and Amphetamine: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Amphetamine
Omeprazole
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Here's what's going on with amphetamine (like Dexedrine or Adderall-type medicines) and omeprazole (Prilosec). Your body clears amphetamine partly through your urine, and how much you clear depends on how acidic or alkaline that urine is. Medicines that make your urine more alkaline can slow that clearing, so amphetamine can build up and its effects (and side effects like jitteriness, fast heartbeat, trouble sleeping, or feeling on edge) may become stronger.
The good news is this is a theoretical concern, and your care team can manage it easily. Please don't stop either medicine on your own. Just let your pharmacist or doctor know you take both so they can keep an eye on how you're feeling.
Effect: Potential increased amphetamine exposure and potentiated pharmacologic action.
Mechanism: Amphetamine renal elimination is pH dependent. Urinary alkalinization increases the non-ionized fraction, promoting tubular reabsorption and prolonging half-life. The proposed link with omeprazole is via GI/urinary alkalinization.
- Direction: Increased amphetamine levels/effect (neither drug is a prodrug here).
- Evidence: Theoretical; onset unspecified.
- Severity on file: Major.
Management: Monitor for sympathomimetic excess (tachycardia, hypertension, agitation, insomnia, appetite loss). Amphetamine dose may be adjusted and individualized; increase clinical monitoring. Consider alternatives if effects are pronounced.
What happens
Increased exposure to amphetamine
Interaction Deep Dive
Do not combine amphetamines with alkalizing agents affecting the gastrointestinal1 or urinary tract, since this combination can lead to elevated amphetamine blood concentrations and enhanced amphetamine effects 2. Because amphetamine clearance depends on pH, alkalinization of the urine will markedly prolong its half-life 1.
Why it happens (mechanism)
Decreased renal elimination
How to manage this interaction
This interaction can usually be handled well by your care team. Here is what to expect and what you can do:
- Keep taking both exactly as prescribed unless your prescriber tells you otherwise.
- Your team may monitor you more closely for stronger amphetamine effects, such as a racing heart, higher blood pressure, restlessness, or trouble sleeping.
- If needed, your amphetamine dose may be adjusted and individualized by your care team.
- Tell your pharmacist or doctor that you take both, and report any new or worsening jitteriness, heart pounding, or sleep problems.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Omeprazole and Amphetamine together?
Omeprazole may raise amphetamine levels by making urine more alkaline and slowing its clearance, so watch for stronger stimulant effects and let your care team monitor and adjust your dose. Do not change either medicine on your own. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Omeprazole and Amphetamine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Omeprazole and Amphetamine interaction managed?
This interaction can usually be handled well by your care team. Here is what to expect and what you can do: Keep taking both exactly as prescribed unless your prescriber tells you otherwise. Your team may monitor you more closely for stronger amphetamine effects, such as a racing heart, higher blood pressure, restlessness, or trouble sleeping. If needed, your amphetamine dose may be adjusted and i… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
- Can Allergy Medication Cause A Positive Amphetamine Drug Test?
- Can Vyvanse Cause A Positive Amphetamine Drug Test?
- How Much Amphetamine Do Adderall XR Products Contain?
- Is Sea Moss Safe To Take With Omeprazole?
- Interaction Question: Omeprazole, Spironolactone And Phentermine
- How To Dose Omeprazole And Sucralfate Together
Questions for your pharmacist
- Does my dose of Omeprazole or Amphetamine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: Desoxyn(R) oral tablets, methamphetamine HCl oral tablets. Recordati Rare Diseases Inc (per FDA), Lebanon, NJ, 2017.
- Product Information: EVEKEO ODT(TM) orally disintegrating tablets, amphetamine sulfate orally disintegrating tablets. Arbor Pharmaceuticals LLC (per FDA), Atlanta, GA, 2019.
Keep reading about Amphetamine
Keep reading about Omeprazole
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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