Omeprazole

Name: Omeprazole Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

142 interactions 106 explained in plain English 955 cited references

Also sold as: Gastrobim Prilosec Prilosec® Prilosec® OTC Primeguard Talicia (as a combination product containing Amoxicillin, Omeprazole, Rifabutin) UlcerGard

About Omeprazole

A proton-pump inhibitor used to treat acid reflux, heartburn, and stomach ulcers. Read the full Omeprazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Rilpivirine Acalabrutinib Amphetamine Octreotide Injection Diazepam Rectal

2 Contraindicated 114 Major 23 Moderate 3 Minor

All (142) Contraindicated (2) Major (114) Moderate (23) Minor (3)

Minor

Omeprazole Fluvastatin Lescol Increased fluvastatin serum concentrations Details Omeprazole Ponatinib Iclusig Explained Decreased ponatinib efficacy Details Omeprazole Helicobacter Pylori Breath Test Explained False-negative 13C-urea breath test results Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.