Omeprazole

142 interactions 106 explained in plain English 955 cited references
Also sold as: Gastrobim Prilosec Prilosec® Prilosec® OTC Primeguard Talicia (as a combination product containing Amoxicillin, Omeprazole, Rifabutin) UlcerGard
About Omeprazole

A proton-pump inhibitor used to treat acid reflux, heartburn, and stomach ulcers. Read the full Omeprazole drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Rilpivirine Acalabrutinib Amphetamine Octreotide Injection Diazepam Rectal
2 Contraindicated 114 Major 23 Moderate 3 Minor
All (142) Contraindicated (2) Major (114) Moderate (23) Minor (3)

Moderate

Omeprazole Alprazolam Xanax Explained Benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Omeprazole Armodafinil Nuvigil Explained Increased omeprazole exposure Details Omeprazole Artemether Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Omeprazole Cenobamate Xcopri Explained Increased exposure to CYP2C19 substrates and/or increased risk of adverse effects Details Omeprazole Cyclosporine Atopica Explained Altered cycloSPORINE concentrations and increased omeprazole exposure Details Omeprazole Doxycycline Acticlate Explained Reduced doxycycline efficacy Details Omeprazole Ginkgo Explained Reduced omeprazole effectiveness and increased risk of bleeding Details Omeprazole Iron Explained Reduced iron salts absorption Details Omeprazole Kratom Explained Increased CYP3A substrate exposure Details Omeprazole Levothyroxine Ermeza Reduced efficacy of levothyroxine and an increased risk of hypothyroidism Details Omeprazole Midazolam Explained Benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Omeprazole Mitapivat Aqvesme Reduced CYP2C19 substrate exposure Details Omeprazole Piperaquine Explained Increased exposure of CYP2C19 substrates Details Omeprazole Propranolol Hemangeol Explained Increased propranolol exposure Details Omeprazole Raltegravir Isentress Explained Increased serum raltegravir concentrations Details Omeprazole Risedronate Actonel Explained Increased risedronate bioavailability Details Omeprazole Tipranavir Aptivus Explained Decreased omeprazole concentrations Details Omeprazole Triazolam Halcion Explained Benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Omeprazole Cranberry Explained Reduced effectiveness of proton pump inhibitors Details Omeprazole Urine Substance Measurement Explained False-positive urine screening tests for tetrahydrocannabinol (THC) Details Omeprazole Doxycycline Injection Acticlate Reduced doxycycline efficacy Details Omeprazole Midazolam Nasal Spray Nayzilam Benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Omeprazole Midazolam Injection Nayzilam Benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.