Omeprazole and Dasabuvir: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Omeprazole
Dasabuvir
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
You've been prescribed omeprazole (a stomach acid reducer) and dasabuvir (part of a hepatitis C treatment). When taken together, omeprazole can cause more dasabuvir to build up in your blood, which may raise the chance of side effects from the hepatitis C medicine. At the same time, the omeprazole itself may not work quite as well, so your heartburn or reflux symptoms could creep back.
The good news is that this is something your care team can plan around. They may keep your omeprazole dose on the lower side, watch how you feel, and adjust things if needed. Please don't change either medicine on your own, just let your pharmacist or doctor know how you're doing.
Effect: Increased dasabuvir exposure with a possible decrease in omeprazole concentration.
Mechanism: Dasabuvir is a BCRP substrate; omeprazole inhibits BCRP efflux, reducing dasabuvir efflux and raising its plasma levels. The reciprocal drop in omeprazole levels is via an unclear mechanism. Neither is an activation-dependent prodrug here.
- Direction: Increased dasabuvir effect; potentially reduced omeprazole effect.
- Evidence: Theoretical; onset unspecified.
- Management: Avoid omeprazole doses >40 mg/day. Monitor for dasabuvir-related adverse events. Monitor for loss of acid-suppression efficacy; a dose increase may be individualized in symptomatic patients.
What happens
Increased dasabuvir concentration; decreased omeprazole concentration
Interaction Deep Dive
When dasabuvir (a substrate of BCRP) is taken together with omeprazole (a BCRP inhibitor), plasma levels of dasabuvir may rise. Omeprazole concentrations, on the other hand, may fall. Watch for reduced omeprazole effectiveness and, in patients who remain symptomatic, consider raising the dose. Do not use omeprazole at doses exceeding 40 mg/day1. Also observe for a rise in adverse events linked to dasabuvir.
Why it happens (mechanism)
Inhibition of dasabuvir BCRP efflux transport; unknown mechanism
How to manage this interaction
Keep taking both medicines exactly as prescribed unless your care team tells you otherwise. Here is how a team typically manages this:
- Dose limits: Omeprazole is generally kept at or below 40 mg per day when used with dasabuvir.
- Watching dasabuvir side effects: Your team may monitor you more closely for any new or worsening symptoms.
- Watching acid control: If reflux or heartburn returns, tell your team; the omeprazole dose may be adjusted and individualized for you.
Report any bothersome symptoms to your pharmacist or prescriber so they can tailor your treatment.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Omeprazole and Dasabuvir together?
Taking omeprazole with dasabuvir may raise dasabuvir levels (more side effect risk) and lower omeprazole's effect; keep omeprazole at 40 mg/day or less and let your care team monitor and adjust as needed. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Omeprazole and Dasabuvir interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Omeprazole and Dasabuvir interaction managed?
Keep taking both medicines exactly as prescribed unless your care team tells you otherwise. Here is how a team typically manages this: Dose limits: Omeprazole is generally kept at or below 40 mg per day when used with dasabuvir. Watching dasabuvir side effects: Your team may monitor you more closely for any new or worsening symptoms. Watching acid control: If reflux or heartburn returns, tell your… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Omeprazole or Dasabuvir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VIEKIRA PAK oral tablets, ombitasvir paritaprevir ritonavir oral tablets and dasabuvir oral tablets. AbbVie Inc. (per manufacturer), North Chicago, Il, 2014.
Keep reading about Omeprazole
Keep reading about Dasabuvir
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