Palonosetron

17 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Granisetron Transdermal Patch Granisetron Injection Hydromorphone Injection Hydromorphone Rectal Morphine Injection
17 Major
All (17) Major (17)

Major

Palonosetron Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Palonosetron Amitriptyline Elavil Explained An increased risk of serotonin syndrome Details Palonosetron Sertraline Explained An increased risk of serotonin syndrome Details Palonosetron Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Palonosetron Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Palonosetron Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Palonosetron Dolasetron Anzemet An increased risk of serotonin syndrome Details Palonosetron Dolasetron Injection Anzemet An increased risk of serotonin syndrome Details Palonosetron Fentanyl Transdermal Patch Duragesic® An increased risk of serotonin syndrome Details Palonosetron Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Palonosetron Granisetron Injection Granisol Increased risk of serotonin syndrome Details Palonosetron Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Palonosetron Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Palonosetron Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Palonosetron Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Palonosetron Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Palonosetron Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.