Procarbazine

44 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Procarbazine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Procarbazine Amitriptyline Elavil Explained Neurotoxicity, seizures Details Procarbazine Sertraline Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Procarbazine Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Procarbazine Diethylpropion Tenuate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Procarbazine Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Procarbazine Levodopa Oral Inhalation Inbrija Hypertensive crisis Details Procarbazine Linezolid Injection Zyvox An increased risk of hypertensive crisis (headache, palpitation, neck stiffness) or seizure Details Procarbazine Maprotiline Ludiomil® An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Procarbazine Methyldopa Aldomet® Hypertensive crisis (headache, palpitation, neck stiffness) Details Procarbazine Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Procarbazine Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Procarbazine Morphine Injection Astramorph® PF Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details

Major

Procarbazine Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular adverse effects Details Procarbazine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome or opioid-related toxicity Details Procarbazine Atropine Ophthalmic Atropine Care 1% Potential to cause hypertensive crisis Details Procarbazine Butorphanol Injection Butorphic Increased risk of serotonin syndrome or opioid toxicity Details Procarbazine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome or opioid toxicity Details Procarbazine Dolasetron Anzemet Increased risk of serotonin syndrome Details Procarbazine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Procarbazine Fentanyl Transdermal Patch Duragesic® Potentiation of opioid effects and an increased risk of serotonin syndrome Details Procarbazine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Procarbazine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Procarbazine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome or opioid toxicity Details Procarbazine Hydromorphone Rectal available generically Increased risk of serotonin syndrome or opioid toxicity Details Procarbazine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Procarbazine Metoclopramide Injection Gimoti Increased risk of hypertensive crisis Details Procarbazine Metoclopramide Nasal Spray Gimoti Increased risk of hypertensive crisis Details Procarbazine Nalbuphine Injection Nubain® Increased risk of serotonin syndrome or opioid toxicity Details Procarbazine Olodaterol Oral Inhalation Striverdi Potentiated cardiovascular effects Details Procarbazine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.