Procarbazine
44 interactions 6 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Morphine Injection
Amitriptyline
Methyldopa
Maprotiline
Entacapone
Levodopa Oral Inhalation
Contraindicated
Procarbazine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Procarbazine Amitriptyline Elavil Explained Neurotoxicity, seizures Details Procarbazine Sertraline Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Procarbazine Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Procarbazine Diethylpropion Tenuate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Procarbazine Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Procarbazine Levodopa Oral Inhalation Inbrija Hypertensive crisis Details Procarbazine Linezolid Injection Zyvox An increased risk of hypertensive crisis (headache, palpitation, neck stiffness) or seizure Details Procarbazine Maprotiline Ludiomil® An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Procarbazine Methyldopa Aldomet® Hypertensive crisis (headache, palpitation, neck stiffness) Details Procarbazine Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Procarbazine Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Procarbazine Morphine Injection Astramorph® PF Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome DetailsMajor
Procarbazine Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular adverse effects Details Procarbazine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome or opioid-related toxicity Details Procarbazine Atropine Ophthalmic Atropine Care 1% Potential to cause hypertensive crisis Details Procarbazine Butorphanol Injection Butorphic Increased risk of serotonin syndrome or opioid toxicity Details Procarbazine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome or opioid toxicity Details Procarbazine Dolasetron Anzemet Increased risk of serotonin syndrome Details Procarbazine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Procarbazine Fentanyl Transdermal Patch Duragesic® Potentiation of opioid effects and an increased risk of serotonin syndrome Details Procarbazine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Procarbazine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Procarbazine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome or opioid toxicity Details Procarbazine Hydromorphone Rectal available generically Increased risk of serotonin syndrome or opioid toxicity Details Procarbazine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Procarbazine Metoclopramide Injection Gimoti Increased risk of hypertensive crisis Details Procarbazine Metoclopramide Nasal Spray Gimoti Increased risk of hypertensive crisis Details Procarbazine Nalbuphine Injection Nubain® Increased risk of serotonin syndrome or opioid toxicity Details Procarbazine Olodaterol Oral Inhalation Striverdi Potentiated cardiovascular effects Details Procarbazine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome DetailsModerate
Procarbazine Acarbose Prandase® Explained An increased risk of hypoglycemia Details Procarbazine Diphenhydramine Injection Banophen CNS depression Details Procarbazine Diphenhydramine Topical Afterbite with Antihistamine CNS depression Details Procarbazine Droxidopa Northera Risk of increased blood pressure Details Procarbazine Glimepiride Amaryl An increased risk of hypoglycemia Details Procarbazine Glipizide Glucotrol An increased risk of hypoglycemia Details Procarbazine Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Procarbazine Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Procarbazine Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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