Procarbazine

44 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Morphine Injection Amitriptyline Methyldopa Maprotiline Entacapone Levodopa Oral Inhalation
13 Contraindicated 18 Major 13 Moderate
All (44) Contraindicated (13) Major (18) Moderate (13)

Contraindicated

Procarbazine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Procarbazine Amitriptyline Elavil Explained Neurotoxicity, seizures Details Procarbazine Sertraline Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Procarbazine Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Procarbazine Diethylpropion Tenuate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Procarbazine Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Procarbazine Levodopa Oral Inhalation Inbrija Hypertensive crisis Details Procarbazine Linezolid Injection Zyvox An increased risk of hypertensive crisis (headache, palpitation, neck stiffness) or seizure Details Procarbazine Maprotiline Ludiomil® An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Procarbazine Methyldopa Aldomet® Hypertensive crisis (headache, palpitation, neck stiffness) Details Procarbazine Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Procarbazine Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Procarbazine Morphine Injection Astramorph® PF Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.