Revefenacin

18 interactions 2 explained in plain English
Also sold as: Yupelri
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ipratropium Oral Inhalation Diphenhydramine Topical Gemfibrozil Glycopyrronium Topical Ipratropium Nasal Spray Leniolisib
17 Major 1 Moderate
All (18) Major (17) Moderate (1)

Major

Revefenacin Amitriptyline Elavil Explained Increased risk of anticholinergic side effects Details Revefenacin Trospium / Xanomeline Cobenfy Explained Increased risk of anticholinergic side effects Details Revefenacin Aclidinium Oral Inhalation Tudorza Increased risk of anticholinergic side effects Details Revefenacin Atropine Ophthalmic Atropine Care 1% Increased risk of anticholinergic side effects Details Revefenacin Cyclopentolate Ophthalmic Akpentolate® Increased risk of anticholinergic side effects Details Revefenacin Cyclosporine Injection Atopica Increased exposure of the active metabolite of revefenacin Details Revefenacin Cyclosporine Ophthalmic Cequa Increased exposure of the active metabolite of revefenacin Details Revefenacin Darolutamide Nubeqa Increased exposure of OATP1B1 or OATP1B3 substrates Details Revefenacin Diphenhydramine Injection Banophen Increased risk of anticholinergic side effects Details Revefenacin Diphenhydramine Topical Afterbite with Antihistamine Increased risk of anticholinergic side effects Details Revefenacin Gemfibrozil Lopid Increased exposure of the active metabolite of revefenacin Details Revefenacin Glycopyrronium Topical Cuvposa® Increased risk of anticholinergic side effects Details Revefenacin Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of anticholinergic side effects Details Revefenacin Ipratropium Oral Inhalation Atrovent® HFA Increased risk of anticholinergic side effects Details Revefenacin Leflunomide Arava Increased exposure of OATP1B1/1B3 substrate Details Revefenacin Leniolisib Joenja Increased OATP1B1/OATP1B3 substrate exposure Details Revefenacin Midostaurin Rydapt Increased OATP1B1 substrate exposure Details

Moderate

Revefenacin Encorafenib Braftovi Increased OATP1B1 substrate exposure, increased OATP1B3 substrate exposure, increased risk of OATP1B1 substrate-related toxicities... Details

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