Drug Interaction Report

Scopolamine and Fentanyl Transdermal Patch: Interaction Details

A pharmacist-reviewed analysis of the Scopolamine and Fentanyl Transdermal Patch interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Scopolamine

Pamine
+

Fentanyl Transdermal Patch

Duragesic®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
LinkedIn
Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 32 documented Scopolamine interactions, 32 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Increased or potentiated scopolamine effects, an increased risk of CNS depression and an increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus

Interaction Deep Dive

Concomitant use of fentaNYL and scopolamine may result in increased risk of urinary retention or severe constipation, which may lead to paralytic ileus3 and also an increased risk of drowsiness, dizziness, disorientation. Choose either drug, depending on the importance of the drug to the patient. If the coadministration cannot be avoided, monitor patients for CNS adverse reactions 4. Monitor patients for signs of urinary retention or reduced gastric motility 321.

Why it happens (mechanism)

Additive CNS depression; unknown

Common questions

Can I take Scopolamine and Fentanyl Transdermal Patch together?

Increased or potentiated scopolamine effects, an increased risk of CNS depression and an increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Always confirm with your pharmacist or prescriber before making any change.

How serious is the Scopolamine and Fentanyl Transdermal Patch interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Scopolamine or Fentanyl Transdermal Patch need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (4)

  1. Product Information: ACTIQ(R) oral transmucosal lozenge, fentanyl citrate oral transmucosal lozenge. Teva Pharmaceuticals USA, Inc. (per FDA), Parsippany, NJ, 2023. DailyMed
  2. Product Information: Fentanyl citrate intravenous, intramuscular injection, fentanyl citrate intravenous, intramuscular injection. Hospira Inc (per FDA), Lake Forest, IL, 2023. DailyMed
  3. Product Information: FENTORA(R) buccal tablets, fentanyl citrate buccal tablets. Teva Pharmaceuticals USA Inc (per FDA), Parsippany, NJ, 2023.
  4. Product Information: TRANSDERM SCOP transdermal system patch, scopolamine transdermal system patch. Baxter Healthcare Corporation (per FDA), Deerfield, IL, 2025. DailyMed
Was this write-up helpful?
Scopolamine

Keep reading about Scopolamine

All Scopolamine interactions (32)
Also serious with: Butorphanol Injection Nalbuphine Injection Cetirizine Ophthalmic Diphenhydramine Topical
Fentanyl Transdermal Patch

Keep reading about Fentanyl Transdermal Patch

All Fentanyl Transdermal Patch interactions (493) Fentanyl Transdermal Patch drug information
Also serious with: Ensitrelvir Samidorphan Safinamide Phenelzine
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Scopolamine + Activated Charcoal Grapefruit Henbane Scopolia Angel's Trumpet Bacopa Belladonna Betel Nut + 43 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.