Selegiline and Linezolid Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Selegiline
Linezolid Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Hypertensive crisis (headache, palpitation, neck stiffness) or seizure
Interaction Deep Dive
Concurrent use of selegiline with another MAOI is contraindicated. Do not use another MAO inhibitor within 14 days of oral selegiline use1. For transdermal selegiline, discontinue any other MAO inhibitor for 4 to 5 half-lives prior to initiation. Do not initiate any other MAO inhibitor within 2 weeks of discontinuation of transdermal selegiline 2.
Why it happens (mechanism)
Additive monoamine oxidase inhibition
Common questions
Can I take Selegiline and Linezolid Injection together?
Hypertensive crisis (headache, palpitation, neck stiffness) or seizure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Selegiline and Linezolid Injection interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Selegiline or Linezolid Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: ZELAPAR(R) oral disintegrating tablets, selegiline HCl disintegrating tablets. Valeant Pharmaceuticals North America LLC (per DailyMed), Bridgewater, NJ, 2014. DailyMed
- Product Information: EMSAM(R) transdermal system, selegiline transdermal system. Mylan Specialty L.P. (per FDA), Morgantown, WV, 2015. DailyMed
Keep reading about Selegiline
Keep reading about Linezolid Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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