Drug Interaction Report

Telavancin and Alfuzosin: Interaction Details

A pharmacist-reviewed analysis of the Telavancin and Alfuzosin interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Alfuzosin

UroXatral Uroxatral®
+

Telavancin

Vibativ
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 55 documented Telavancin interactions, 53 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

An increased risk of QT interval prolongation

Interaction Deep Dive

Both alfuzosin and telavancin have been associated with QT interval prolongation. Use caution with the concomitant use these agents due to the potential for additive effects on QT interval prolongation and an increase in the risk of serious cardiac events, including ventricular arrhythmias and/or torsade de pointes12. If coadministration is required, monitoring for QT interval prolongation may be warranted.

Why it happens (mechanism)

Additive effects on QT interval prolongation

Literature reports

1 report — tap to read

a) In a postmarketing study that evaluated the effect of concomitant administration of alfuzosin with another QT interval-prolonging drug of similar effect size, the observed QT interval prolongation was greater than that seen with either drug alone, but was not more than additive. The corrected (Fridericia) QT interval (QTcF) increased by 5.9 milliseconds (upper bound of 95% confidence interval (CI), 9.4 milliseconds). The QTcF increase observed with moxifloxacin 400 mg (positive control) was 10.2 milliseconds (upper bound 95% CI, 13.8 milliseconds). The mean placebo-subtracted QTcF increase following administration of alfuzosin 10 mg alone was 1.9 milliseconds (upper bound 95% CI, 5.5 milliseconds) 1.

Common questions

Can I take Telavancin and Alfuzosin together?

An increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.

How serious is the Telavancin and Alfuzosin interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Telavancin or Alfuzosin need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (2)

  1. Product Information: UROXATRAL(R) oral extended-release tablets, alfuzosin HCl oral extended-release tablets. Sanofi-Aventis U.S. LLC, Bridgewater, NJ, 2010. DailyMed
  2. Product Information: VIBATIV IV injection, telavancin IV injection. Theravance, Inc. South San Francisco, CA, 2009.
Was this write-up helpful?
Alfuzosin

Keep reading about Alfuzosin

All Alfuzosin interactions (297) Alfuzosin drug information
Also serious with: Ritonavir Saquinavir Sparfloxacin Posaconazole
Telavancin

Keep reading about Telavancin

All Telavancin interactions (55)
Also serious with: Heparin Injection Heparin Sertraline Oxaliplatin Injection
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Alfuzosin + Activated Charcoal Grapefruit St. John's Wort Acacia Rigidula Adrafinil African Wild Potato American Elder Astaxanthin + 131 more
Telavancin + Bacillus Coagulans Bacillus Subtilis Bifidobacterium Animalis Subsp. Lactis Bifidobacterium Bifidum Bifidobacterium Breve Bifidobacterium Longum Fermented Milk Flaxseed + 19 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.