Telavancin and Levofloxacin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Levofloxacin
Telavancin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of QT interval prolongation
Interaction Deep Dive
Avoid concomitant use of levoFLOXacin together with another agent known to cause QT-interval prolongation. Concomitant use may result in additive effects on the QT interval and increase the risk of cardiac adverse events, including arrhythmia and torsade de pointes. The elderly and patients with risk factors for torsade de pointes (known QT prolongation, uncorrected hypokalemia) may be more susceptible to QT interval effects1.
Why it happens (mechanism)
Additive QT interval prolongation
Common questions
Can I take Telavancin and Levofloxacin together?
Increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Telavancin and Levofloxacin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Telavancin or Levofloxacin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LEVAQUIN(R) oral film coated tablets, solution, intravenous injection solution, concentrate, levofloxacin oral film coated tablets, solution, intravenous injection solution, concentrate. Janssen Pharmaceuticals, Inc. (per FDA), Titusville, NJ, 2014. DailyMed
Keep reading about Levofloxacin
Keep reading about Telavancin
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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