Telithromycin and Dihydroergotamine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Telithromycin
No brand names on recordDihydroergotamine Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of acute ergot toxicity
Interaction Deep Dive
Coadministration of an ergotamine and telithromycin (a strong CYP3A4 inhibitor) is contraindicated. Serious and life-threatening cases of peripheral ischemia, vasospasm, and cerebral ischemia have been associated with concurrent use of other known strong CYP3A inhibitors (eg, protease inhibitors, macrolide antibiotics)1.
Why it happens (mechanism)
Inhibition of CYP3A-mediated ergot derivative metabolism by telithromycin
Common questions
Can I take Telithromycin and Dihydroergotamine Injection together?
An increased risk of acute ergot toxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Telithromycin and Dihydroergotamine Injection interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Telithromycin or Dihydroergotamine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Ergomar(R) sublingual tablets, ergotamine tartrate sublingual tablets. TerSera Therapeutics LLC (per DailyMed), Cedar Rapids, IA, 2016. DailyMed
Keep reading about Telithromycin
Keep reading about Dihydroergotamine Injection
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