Telithromycin

146 interactions 11 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Telithromycin Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Telithromycin Simvastatin Flolipid Explained Increased risk of myopathy or rhabdomyolysis Details Telithromycin Alfuzosin UroXatral Increased alfuzosin plasma concentrations and an increased risk of QT interval prolongation Details Telithromycin Dihydroergotamine Injection DHE-45® Injection An increased risk of acute ergot toxicity Details Telithromycin Dihydroergotamine Nasal Spray Migranal An increased risk of acute ergot toxicity Details Telithromycin Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Telithromycin Ivabradine Corlanor Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Telithromycin Ketoconazole Topical Extina® Foam Increased telithromycin exposure, an increased ketoconazole exposure and an increased risk for QT interval prolongation Details Telithromycin Lovastatin Altocor® Increased lovastatin plasma levels and an increased risk of myopathy or rhabdomyolysis Details Telithromycin Lurasidone Latuda Increased lurasidone exposure Details Telithromycin Methylergonovine Methergine An increased risk of acute ergot toxicity Details Telithromycin Naloxegol Movantik Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Telithromycin Nimodipine Nimotop Increased serum nimodipine concentrations Details

Major

Telithromycin Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Telithromycin Abametapir Explained Increased exposure of CYP3A4 substrate Details Telithromycin Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Telithromycin Sertraline Explained An increased risk of QT interval prolongation Details Telithromycin Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Telithromycin Relugolix Orgovyx Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Telithromycin Acalabrutinib Calquence Increased acalabrutinib exposure Details Telithromycin Ado-Trastuzumab Emtansine Injection KADCYLA Increased exposure of cytotoxic component DM1 (maytansine derivative) and risk of toxicity Details Telithromycin Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Telithromycin Apixaban Eliquis Explained Increased apixaban exposure and an increased risk of bleeding Details Telithromycin Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Telithromycin Aripiprazole Injection Abilify Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Telithromycin Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Telithromycin Asciminib Scemblix Increased asciminib exposure and an increased risk of asciminib-related adverse effects Details Telithromycin Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Telithromycin Atogepant Qulipta Increased atogepant exposure Details Telithromycin Avapritinib Ayvakit Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Telithromycin Azithromycin AzaSite An increased risk of QT interval prolongation Details Telithromycin Atorvastatin Atorvaliq Increased atorvastatin plasma levels, thereby increasing the risk of myopathy or rhabdomyolysis Details Telithromycin Cariprazine Vraylar Explained Increased exposure to cariprazine and its active metabolite, didesmethylcariprazine Details Telithromycin Amlodipine Amvaz® Increased amLODIPine exposure and an increased risk of hypotension and edema Details Telithromycin Anagrelide Agrylin Increased risk of QT interval prolongation Details Telithromycin Avanafil Stendra Decreased avanafil clearance and increased avanafil plasma concentration Details Telithromycin Axitinib Inlyta Increased axitinib plasma concentrations Details Telithromycin Beclomethasone Nasal Spray Beconase Increased beclomethasone exposure and an increased risk of beclomethasone-related adverse reactions Details Telithromycin Beclomethasone Oral Inhalation Beclovent® Increased beclomethasone exposure and an increased risk of beclomethasone-related adverse reactions Details Telithromycin Bedaquiline Sirturo Increased bedaquiline exposure and an increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.