Drug & supplement interaction

1-androsterone + Trazodone

Trazodone brand names: Desyrel, Oleptro.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between 1-androsterone and Trazodone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

1-androsterone and Trazodone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trazodone and 1-androsterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

1-androsterone safety at a glance

1-androsterone overall Avoid It is a hormonal compound with real health risks and little safety testing.
Pregnancy Avoid Hormone-altering prohormones should never be used during pregnancy.
Breastfeeding Avoid Avoid while breastfeeding because of unknown hormonal risks to the baby.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trazodone and 1-androsterone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Trazodone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Trazodone is filed under 8 classifications — including antidepressant drugs, serotonergic drugs, serotonergic drugs. 1-androsterone has documented interactions with 1 drug class — the most serious being testosterone (moderate) — and none of Trazodone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

1-androsterone Does Interact With Other Medications

1-androsterone has 8 moderate known drug interactions in our database — Trazodone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 8 No known interaction 2,822 (incl. Trazodone)
Taking anything else?

Check Another of Your Medications Against 1-androsterone

Covers the 2,830 medications we’ve checked against 1-androsterone. Pick one to open its full report.

What to actually watch for

What 1-androsterone Itself Has Been Linked To

This is not an interaction — nothing below involves Trazodone. It is the side-effect record for 1-androsterone on its own, from the licensed Natural Medicines monograph. If something new turns up after you add 1-androsterone, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    “Significant increases in serum creatinine of around 0.2 mg/dL and significant decreases in GFR of around 16.4 mL/min/1.72m2 have been reported in patients taking 1-androsterone for 4 weeks. Serum creatinine remained within normal range despite the elevation, GFR dropped below 89 mL/min/1.72m2, which is suggestive of renal impairment.”

    1-androsterone · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 91095. Granados J, Gillum TL, Christmas KM, et al. Prohormone supplement 3b-hydroxy-5a-androst-1-en-17-one enhances resistance training gains but impairs user health. J Appl Physiol (1985). 2014;116(5):560-9.
  • Liver problems Worth acting on Additional detail

    “There is currently a limited amount of information on the adverse effects of 1-androsterone. A thorough evaluation of safety outcomes has not been conducted.

    Most Common Adverse Effects:

    Orally: Dyslipidemia, transaminitis, renal dysfunction.”

    1-androsterone · Natural Medicines adverse-effect record, reported in dyslipidemia.

Everything above comes from the Natural Medicines adverse-effect record for 1-androsterone — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Trazodone’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Trazodone column appears here.

From our Q&A

Questions About 1-androsterone or Trazodone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 1-androsterone or Trazodone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Trazodone

This page covers 1-androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trazodone page lists 197 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Lithium (major) and Siberian Cocklebur (major).

By severity: 7 major · 151 moderate · 39 minor.

From our pharmacist’s overview on the Trazodone page

“St. John's wort tops my worry list with trazodone (Desyrel, Oleptro), the antidepressant many people also take for sleep.”

Reviewed by 2 · Jul 18, 2026

Open the Trazodone interaction page

One more smart check

Taking 1-androsterone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 35 real supplement products containing 1-androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 1-androsterone. Even though 1-androsterone itself has no known interaction with Trazodone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 1-androsterone and Trazodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 1-androsterone
Top half

#562 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trazodone
Top 5%

#111 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1-androsterone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 1-androsterone and Trazodone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 1-androsterone

What is 1-androsterone?

1-androsterone
  • Muscle building
  • Increasing strength
  • Athletic performance
  • Body recomposition

1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe or effective in quality human studies. It can affect hormones and may harm the liver and other organs, so most pharmacists would recommend avoiding it.

Synthetic compound (not a plant part) · Capsules, tablets, sometimes combined with other prohormones

An interaction check asks whether these two react with each other — it does not ask whether 1-androsterone is a good idea for someone in your situation. Here is what our 1-androsterone record says about it on its own.

1-androsterone: dosing

There is no established safe or standard dose for 1-androsterone, and no medical guideline supports its use. Products vary widely in strength and ingredients.Because of the health risks involved, the safest choice for most people is not to use it at all. Never combine it with other prohormones or hormone products.

From our 1-androsterone monograph — the full record covers uses, side effects and every documented interaction.

Read the full 1-androsterone monograph & all interactions
Medication

About Trazodone

What Is Trazodone Used For?

Brand names: Desyrel, Oleptro

Trazodone is approved to treat major depressive disorder (MDD) in adults. This applies to trazodone hydrochloride tablets (brands including Trazodone HCl and Trazodone Hydrochloride) and to Raldesy, the oral solution form of trazodone.

It is not approved for use in children or adolescents.

See full Trazodone drug information
Keep checking

Other Drugs & 1-androsterone

Browse every other medication we’ve checked against 1-androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
8Moderate
0Minor
2,821No known interaction
8 Moderate 2,821 No interaction
Moderate

8 interactions

No interaction 2,821 drugs checked — show the list

We also checked 1-androsterone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full 1-androsterone list.

See the full 1-androsterone interactions page
See every supplement checked against Trazodone, ranked by severity
Evidence & sources

1-androsterone References

The 2 references that drive our 1-androsterone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Parr MK, Opfermann G, Geyer H, et al. Seized designer supplement named "1-Androsterone": identification as 3ß-hydroxy-5a-androst-1-en-17-one and its urinary elimination. Steroids 2011;76(6):540-7.
  2. Granados J, Gillum TL, Christmas KM, et al. Prohormone supplement 3b-hydroxy-5a-androst-1-en-17-one enhances resistance training gains but impairs user health. J Appl Physiol (1985). 2014;116(5):560-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 1-androsterone and Trazodone Together: Common Questions

Is it safe to take 1-androsterone with Trazodone?
We do not list a known interaction between 1-androsterone and Trazodone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the 1-androsterone and Trazodone combination checked?
Interactions in our licensed database are recorded against drug classes. Trazodone is filed under 8 classifications, and 1-androsterone has documented interactions with 1 drug class — none of Trazodone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 1-androsterone interact with any other medications?
Yes. 1-androsterone has 8 documented drug interactions in our database — Trazodone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Trazodone interact with any supplements?
Yes. Trazodone has documented interactions with 197 supplements in our database — 1-androsterone is not one of them. The Trazodone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

1-androsterone monograph Uses, safety profile, and every drug interaction in one place Trazodone drug information The full plain-English guide to this medication Trazodone supplement interactions Every supplement checked against Trazodone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trazodone and 1-androsterone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.