Drug & supplement interaction

19-nor-dhea + Lidocaine

Lidocaine brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, and others.

No Known Interaction
The bottom line No known interaction

We found no known interaction between 19-nor-dhea and Lidocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

19-nor-dhea and Lidocaine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lidocaine and 19-nor-dhea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

19-nor-dhea safety at a glance

19-nor-dhea overall Avoid It is an unproven hormonal prohormone with potential serious side effects and little safety data.
Pregnancy Avoid Hormone-altering products should not be used during pregnancy.
Breastfeeding Avoid Avoid while breastfeeding due to hormonal effects and lack of safety data.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lidocaine and 19-nor-dhea? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lidocaine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lidocaine is filed under 5 classifications — including anesthesia, cytochrome p450 2d6 (cyp2d6) substrates, topical drugs. 19-nor-dhea has documented interactions with 1 drug class — the most serious being testosterone (moderate) — and none of Lidocaine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

19-nor-dhea Does Interact With Other Medications

19-nor-dhea has 8 moderate known drug interactions in our database — Lidocaine isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against 19-nor-dhea

Covers the 2,830 medications we’ve checked against 19-nor-dhea. Pick one to open its full report.

What to actually watch for

What Lidocaine’s Own FDA Label Lists

This is not an interaction — none of it involves 19-nor-dhea. These are the most notable effects listed in the ADVERSE REACTIONS section of Lidocaine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Wheezing Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Shortness of breath Worth acting on mentioned in 3.8% of FDA reports for Lidocaine
  • Low mood Worth acting on
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on
  • Bleeding or bruising Worth acting on
  • An allergic reaction Worth acting on

Showing the 10 most notable of 27 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed › Where a percentage is shown, it is the share of 96,036 voluntary FDA FAERS reports for Lidocaine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. 19-nor-dhea’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no 19-nor-dhea side to compare — that is a limit of the record, not a statement that 19-nor-dhea has no side effects.

Everything else you take

See Every Supplement That Interacts With Lidocaine

This page covers 19-nor-dhea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lidocaine page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Fever Bark (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 111 moderate · 31 minor.

From our pharmacist’s overview on the Lidocaine page

“Lidocaine (Xylocaine) deserves genuine care on this page, and I would learn its three major-rated entries first. Grapefruit and St.”

Reviewed by 2 · Jul 18, 2026

Open the Lidocaine interaction page

One more smart check

Taking 19-nor-dhea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing 19-nor-dhea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 19-nor-dhea. Even though 19-nor-dhea itself has no known interaction with Lidocaine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 19-nor-dhea and Lidocaine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 19-nor-dhea
Steady interest

#1,052 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lidocaine
Top 10%

#237 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. 19-nor-dhea is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 19-nor-dhea reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 19-nor-dhea and Lidocaine records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 19-nor-dhea

What is 19-nor-dhea?

  • Muscle building and bodybuilding
  • Increasing strength
  • Athletic performance
  • Supporting hormone levels
  • Body recomposition

19-nor-DHEA is a synthetic 'prohormone' marketed to bodybuilders as a precursor to nandrolone-like compounds, not a natural plant supplement. There is very little reliable human research on its safety or effectiveness, and products like it carry real risks to the liver, hormones, and heart. We do not recommend using it without close medical supervision, and it may be banned in sports and restricted by law in some places.

Not applicable (a synthetic or semi-synthetic hormone derivative, not a plant part) · Capsules, tablets, sublingual tablets, sometimes combined in 'prohormone' supplement blends

An interaction check asks whether these two react with each other — it does not ask whether 19-nor-dhea is a good idea for someone in your situation. Here is what our 19-nor-dhea record says about it on its own.

19-nor-dhea: dosing

There is no established or medically recommended dose for 19-nor-DHEA. It has not been studied well enough to define a safe and effective amount.Products vary widely, and labels may not be accurate. Because of this, we cannot suggest a specific milligram amount.

From our 19-nor-dhea monograph — the full record covers uses, side effects and every documented interaction.

Read the full 19-nor-dhea monograph & all interactions
Medication

About Lidocaine Transdermal Patch

What Is Lidocaine Transdermal Patch Used For?

Brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, Lidoject-2, Duo-Trach Kit, Octocaine, Lidoderm, Ztlido

Lidocaine skin patches are applied directly to the painful area to treat post-herpetic neuralgia (PHN) — the persistent burning or aching nerve pain that can remain after a shingles outbreak.

Lidoderm (lidocaine patch 5%) and ZTlido (lidocaine topical system 1.8%) are both indicated for this use in adults. Note that despite their different strengths, one ZTlido topical system provides equivalent lidocaine exposure to one Lidoderm patch.

Most-Reported Side Effects for Lidocaine

From FAERS, the FDA’s public side-effect reporting system (96,036 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 4,961 reports
Fatigue 4,867 reports
Headache 4,439 reports
Product quality issue 3,920 reports
Dyspnea 3,658 reports
See full Lidocaine Transdermal Patch drug information
Keep checking

Other Drugs & 19-nor-dhea

Browse every other medication we’ve checked against 19-nor-dhea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
8Moderate
0Minor
2,821No known interaction
Moderate

8 interactions

No interaction 2,821 drugs checked — show the list
Evidence & sources

19-nor-dhea References

The 4 sources that drive our 19-nor-dhea monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. 19-nor-dhea is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. DHEA — MedlinePlus (NIH) Source
  2. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  4. FDA 101: Dietary Supplements — U.S. Food and Drug Administration Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 19-nor-dhea and Lidocaine Together: Common Questions

Is it safe to take 19-nor-dhea with Lidocaine?
We do not list a known interaction between 19-nor-dhea and Lidocaine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the 19-nor-dhea and Lidocaine combination checked?
Interactions in our licensed database are recorded against drug classes. Lidocaine is filed under 5 classifications, and 19-nor-dhea has documented interactions with 1 drug class — none of Lidocaine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 19-nor-dhea interact with any other medications?
Yes. 19-nor-dhea has 8 documented drug interactions in our database — Lidocaine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lidocaine interact with any supplements?
Yes. Lidocaine has documented interactions with 145 supplements in our database — 19-nor-dhea is not one of them. The Lidocaine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Lidocaine and 19-nor-dhea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.