4-androsterone + Netupitant, Palonosetron (Oral)
Netupitant, Palonosetron (Oral) brand name: Akynzeo.
We found no known interaction between 4-androsterone and Netupitant, Palonosetron (Oral) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
4-androsterone and Netupitant, Palonosetron (Oral)
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Netupitant, Palonosetron (Oral) and 4-androsterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
4-androsterone safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Netupitant, Palonosetron (Oral)
Interactions in our licensed database are recorded against drug classes, not just single drug names. Netupitant, Palonosetron (Oral) is filed under 5 classifications — including cytochrome p450 3a4 (cyp3a4) inhibitors, serotonergic drugs, serotonergic drugs. 4-androsterone has documented interactions with 1 drug class — the most serious being testosterone (moderate) — and none of Netupitant, Palonosetron (Oral)’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
4-androsterone Does Interact With Other Medications
4-androsterone has 8 moderate known drug interactions in our database — Netupitant, Palonosetron (Oral) isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 4-androsterone
We haven’t checked that one against 4-androsterone yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 4-androsterone. Pick one to open its full report.
See Every Supplement That Interacts With Netupitant, Palonosetron (Oral)
This page covers 4-androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Netupitant, Palonosetron (Oral) page lists 158 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 5-htp (moderate).
By severity: 4 major · 113 moderate · 41 minor.
From our pharmacist’s overview on the Netupitant, Palonosetron (Oral) page
“Getting Akynzeo (netupitant and palonosetron) to work is the difference between finishing a chemotherapy cycle comfortably and losing days to nausea, so this list warrants genuine care. Most of it involves a liver enzyme, CYP3A4, that clears netupitant.”
Reviewed by 2 · Jul 18, 2026
Taking 4-androsterone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 23 real supplement products containing 4-androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 4-androsterone. Even though 4-androsterone itself has no known interaction with Netupitant, Palonosetron (Oral), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where 4-androsterone and Netupitant, Palonosetron (Oral) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#884 of 1,452 supplements looked up here in the last 7 days
#103 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. 4-androsterone is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 4-androsterone reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The 4-androsterone and Netupitant, Palonosetron (Oral) records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About 4-androsterone
What is 4-androsterone?
- Muscle building
- Strength and athletic performance
- Boosting testosterone
- Bodybuilding cycles
4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human studies are very limited and it carries real risks like liver strain, hormone imbalance, and cholesterol changes. Its legal status is uncertain in many places, and it may cause a positive result on drug tests. We do not recommend it without close medical supervision, and it should be avoided in pregnancy and breastfeeding.
Synthetic steroidal compound (not a plant part) · Capsules, tablets, transdermal gels or creams, liquid drops
An interaction check asks whether these two react with each other — it does not ask whether 4-androsterone is a good idea for someone in your situation. Here is what our 4-androsterone record says about it on its own.
4-androsterone: dosing
There is no established, medically recommended dose for 4-androsterone. Doses used in bodybuilding come from product labels and informal community advice, not from rigorous clinical research.Because purity and strength can vary between products and the risks are significant, we cannot recommend a specific amount. Never assume that a higher dose is safer or more effective.
From our 4-androsterone monograph — the full record covers uses, side effects and every documented interaction.
About Netupitant and Palonosetron
What Is Netupitant and Palonosetron Used For?
Brand name: Akynzeo
Akynzeo capsules are used in adults to prevent both the short-term (acute) and longer-lasting (delayed) nausea and vomiting that can follow cancer chemotherapy — including, but not limited to, highly emetogenic (strongly nausea-causing) chemotherapy regimens. It is always taken together with the steroid dexamethasone.
Akynzeo capsules cover a broad range of chemotherapy regimens, including anthracycline plus cyclophosphamide-based regimens. Each ingredient targets a different stage: palonosetron addresses nausea and vomiting in the first 24 hours, while netupitant covers both the early and the delayed phase that can last several days after treatment.
Other Drugs & 4-androsterone
Browse every other medication we’ve checked against 4-androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
8 interactions
No interaction 2,821 drugs checked — show the list
We also checked 4-androsterone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Sertraline ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Isotretinoin ›
- Warfarin Sodium ›
- Tirzepatide ›
- Amlodipine Besylate ›
- Ibuprofen ›
- Methamphetamine ›
- Docusate ›
- Tadalafil ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Prednisone ›
- Metformin ›
- Amitriptyline ›
- Semaglutide ›
- Lisdexamfetamine ›
- Amphetamine ›
- Levothyroxine, Liothyronine ›
- Propranolol ›
- Methotrexate ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Bendamustine ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Acyclovir ›
- Naproxen ›
- Acetaminophen, Aspirin, Caffeine ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
- Acetaminophen, Codeine ›
Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full 4-androsterone list.
4-androsterone References
The 3 sources that drive our 4-androsterone monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. 4-androsterone is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Anabolic Steroids and Other Appearance and Performance Enhancing Drugs (APEDs) — NIH National Institute on Drug Abuse Source
- Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
- DHEA — MedlinePlus Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking 4-androsterone and Netupitant, Palonosetron (Oral) Together: Common Questions
Is it safe to take 4-androsterone with Netupitant, Palonosetron (Oral)?
How was the 4-androsterone and Netupitant, Palonosetron (Oral) combination checked?
Does 4-androsterone interact with any other medications?
Does Netupitant, Palonosetron (Oral) interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.