Drug & supplement interaction

4-androsterone + Sirolimus

Sirolimus brand name: Rapamune.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between 4-androsterone and Sirolimus in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

4-androsterone and Sirolimus

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sirolimus and 4-androsterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

4-androsterone safety at a glance

4-androsterone overall Use caution Prohormones can disrupt hormones, strain the liver, and affect cholesterol; safety is not well studied.
Pregnancy Avoid Androgenic hormones can harm a developing baby; do not use during pregnancy.
Breastfeeding Avoid Hormonal effects on a nursing infant are unknown and potentially harmful; avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sirolimus and 4-androsterone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sirolimus

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sirolimus is filed under 5 classifications — including immunosuppressants, p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates. 4-androsterone has documented interactions with 1 drug class — the most serious being testosterone (moderate) — and none of Sirolimus’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

4-androsterone Does Interact With Other Medications

4-androsterone has 8 moderate known drug interactions in our database — Sirolimus isn’t one of them. If you take anything else, check it against the full list below.

Moderate 8 No known interaction 2,822 (incl. Sirolimus)
Taking anything else?

Check Another of Your Medications Against 4-androsterone

Covers the 2,830 medications we’ve checked against 4-androsterone. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests 4-androsterone and Sirolimus May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Kidney problems / Liver problems Worth acting on Additional detail

    4-androsterone

    “There is insufficient information available about adverse effects associated with 4-androsterone. It is purported that 4-androsterone is metabolized to anabolic compounds. Therefore, in theory, there is concern that it might cause serious anabolic steroid-like side effects including stroke, kidney failure, and liver injury.”

    4-androsterone · Natural Medicines adverse-effect record, reported in kidney failure.

    Sirolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Sirolimus. Read the label on DailyMed ›

Effects for Sirolimus come from the ADVERSE REACTIONS section of its FDA label; effects for 4-androsterone come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About 4-androsterone or Sirolimus

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 4-androsterone or Sirolimus, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sirolimus

This page covers 4-androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sirolimus page lists 188 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).

By severity: 3 major · 149 moderate · 36 minor.

From our pharmacist’s overview on the Sirolimus page

“Sirolimus (Rapamune) is the anti-rejection medicine transplant patients depend on, and it is a narrow-therapeutic-index drug, meaning small shifts in its blood level can invite rejection on one side or toxicity on the other. That is why the 188 supplements on this page deserve genuine wariness, starting with the three rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Sirolimus interaction page

One more smart check

Taking 4-androsterone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 23 real supplement products containing 4-androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 4-androsterone. Even though 4-androsterone itself has no known interaction with Sirolimus, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 4-androsterone and Sirolimus Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 4-androsterone
Steady interest

#1,033 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sirolimus
Steady interest

#1,451 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. 4-androsterone is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 4-androsterone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 4-androsterone and Sirolimus records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 4-androsterone

What is 4-androsterone?

  • Muscle building
  • Strength and athletic performance
  • Boosting testosterone
  • Bodybuilding cycles

4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human studies are very limited and it carries real risks like liver strain, hormone imbalance, and cholesterol changes. Its legal status is uncertain in many places, and it may cause a positive result on drug tests. We do not recommend it without close medical supervision, and it should be avoided in pregnancy and breastfeeding.

Synthetic steroidal compound (not a plant part) · Capsules, tablets, transdermal gels or creams, liquid drops

An interaction check asks whether these two react with each other — it does not ask whether 4-androsterone is a good idea for someone in your situation. Here is what our 4-androsterone record says about it on its own.

4-androsterone: dosing

There is no established, medically recommended dose for 4-androsterone. Doses used in bodybuilding come from product labels and informal community advice, not from rigorous clinical research.Because purity and strength can vary between products and the risks are significant, we cannot recommend a specific amount. Never assume that a higher dose is safer or more effective.

From our 4-androsterone monograph — the full record covers uses, side effects and every documented interaction.

Read the full 4-androsterone monograph & all interactions
Medication

About Sirolimus

What Is Sirolimus Used For?

Brand name: Rapamune

Sirolimus oral solution and tablets are used to help prevent organ rejection in kidney (renal) transplant patients aged 13 and older. They are also used to treat lymphangioleiomyomatosis (LAM) — a rare lung disease in which abnormal muscle-like cells invade lung tissue.

Fyarro (sirolimus, intravenous injection) is used to treat adults with locally advanced, unresectable, or metastatic malignant PEComa — a rare tumor that grows in soft tissue or organs. Hyftor (sirolimus topical gel) is used to treat facial angiofibroma (small benign skin growths on the face) associated with tuberous sclerosis in adults and children aged 6 and older.

Most-Reported Side Effects for Sirolimus

From FAERS, the FDA’s public side-effect reporting system (13,394 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 525 reports
Diarrhea 515 reports
Pneumonia 487 reports
Acute kidney injury 435 reports
Thrombotic microangiopathy 376 reports
See full Sirolimus drug information
Keep checking

Other Drugs & 4-androsterone

Browse every other medication we’ve checked against 4-androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
8Moderate
0Minor
2,821No known interaction
8 Moderate 2,821 No interaction
Moderate

8 interactions

No interaction 2,821 drugs checked — show the list

We also checked 4-androsterone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full 4-androsterone list.

See the full 4-androsterone interactions page
See every supplement checked against Sirolimus, ranked by severity
Evidence & sources

4-androsterone References

The 3 sources that drive our 4-androsterone monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. 4-androsterone is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Anabolic Steroids and Other Appearance and Performance Enhancing Drugs (APEDs) — NIH National Institute on Drug Abuse Source
  2. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  3. DHEA — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 4-androsterone and Sirolimus Together: Common Questions

Is it safe to take 4-androsterone with Sirolimus?
We do not list a known interaction between 4-androsterone and Sirolimus. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do 4-androsterone and Sirolimus have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the 4-androsterone and Sirolimus combination checked?
Interactions in our licensed database are recorded against drug classes. Sirolimus is filed under 5 classifications, and 4-androsterone has documented interactions with 1 drug class — none of Sirolimus's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 4-androsterone interact with any other medications?
Yes. 4-androsterone has 8 documented drug interactions in our database — Sirolimus is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sirolimus interact with any supplements?
Yes. Sirolimus has documented interactions with 188 supplements in our database — 4-androsterone is not one of them. The Sirolimus interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

4-androsterone monograph Uses, safety profile, and every drug interaction in one place Sirolimus drug information The full plain-English guide to this medication Sirolimus supplement interactions Every supplement checked against Sirolimus, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sirolimus and 4-androsterone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.