4-androsterone + Tipiracil Hydrochloride, Trifluridine
Tipiracil Hydrochloride, Trifluridine brand name: Lonsurf.
We found no known interaction between 4-androsterone and Tipiracil Hydrochloride, Trifluridine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tipiracil Hydrochloride, Trifluridine states a food rule worth keeping to.
4-androsterone and Tipiracil Hydrochloride, Trifluridine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tipiracil Hydrochloride, Trifluridine and 4-androsterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
4-androsterone safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Tipiracil Hydrochloride, Trifluridine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Tipiracil Hydrochloride, Trifluridine is filed under a single classification — oral drugs. 4-androsterone has documented interactions with 1 drug class — the most serious being testosterone (moderate) — and none of Tipiracil Hydrochloride, Trifluridine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
4-androsterone Does Interact With Other Medications
4-androsterone has 8 moderate known drug interactions in our database — Tipiracil Hydrochloride, Trifluridine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 4-androsterone
We haven’t checked that one against 4-androsterone yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 4-androsterone. Pick one to open its full report.
Some Tipiracil Hydrochloride, Trifluridine Products Have a Food Rule — 4-androsterone Should Not Break It
At least one FDA label for a product containing Tipiracil Hydrochloride, Trifluridine says to take it with food. If you take 4-androsterone on an empty stomach out of habit, keep them separate — and take Tipiracil Hydrochloride, Trifluridine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tipiracil Hydrochloride, Trifluridine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Recommended Dosage : 35 mg/m 2 /dose orally twice daily with food on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.
From the Dosage and Administration section of the FDA label we read for Tipiracil Hydrochloride, Trifluridine — where that label names a specific product, the instruction is that product's. See the Tipiracil Hydrochloride, Trifluridine drug page ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Tipiracil Hydrochloride, Trifluridine
This page covers 4-androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tipiracil Hydrochloride, Trifluridine page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
Open the Tipiracil Hydrochloride, Trifluridine interaction page
Taking 4-androsterone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 23 real supplement products containing 4-androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 4-androsterone. Even though 4-androsterone itself has no known interaction with Tipiracil Hydrochloride, Trifluridine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where 4-androsterone and Tipiracil Hydrochloride, Trifluridine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#767 of 1,452 supplements looked up here in the last 7 days
#1,087 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. 4-androsterone is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 4-androsterone reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 4-androsterone and Tipiracil Hydrochloride, Trifluridine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About 4-androsterone
What is 4-androsterone?
- Muscle building
- Strength and athletic performance
- Boosting testosterone
- Bodybuilding cycles
4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human studies are very limited and it carries real risks like liver strain, hormone imbalance, and cholesterol changes. Its legal status is uncertain in many places, and it may cause a positive result on drug tests. We do not recommend it without close medical supervision, and it should be avoided in pregnancy and breastfeeding.
Synthetic steroidal compound (not a plant part) · Capsules, tablets, transdermal gels or creams, liquid drops
An interaction check asks whether these two react with each other — it does not ask whether 4-androsterone is a good idea for someone in your situation. Here is what our 4-androsterone record says about it on its own.
4-androsterone: dosing
There is no established, medically recommended dose for 4-androsterone. Doses used in bodybuilding come from product labels and informal community advice, not from rigorous clinical research.Because purity and strength can vary between products and the risks are significant, we cannot recommend a specific amount. Never assume that a higher dose is safer or more effective.
From our 4-androsterone monograph — the full record covers uses, side effects and every documented interaction.
About Trifluridine and Tipiracil
What Is Trifluridine and Tipiracil Used For?
Brand name: Lonsurf
Lonsurf (trifluridine and tipiracil) is used to treat adults with metastatic colorectal cancer — either alone or combined with bevacizumab — after prior treatment with several other chemotherapy regimens and targeted therapies.
Lonsurf is also used for adults with metastatic gastric or gastroesophageal junction adenocarcinoma (cancer of the stomach or where the stomach meets the esophagus) who have already received at least two prior chemotherapy regimens.
Other Drugs & 4-androsterone
Browse every other medication we’ve checked against 4-androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
8 interactions
No interaction 2,821 drugs checked — show the list
We also checked 4-androsterone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Amitriptyline ›
- Methotrexate ›
- Bendamustine ›
- Acyclovir ›
- Doxycycline ›
- Amphetamine ›
- Fluoxetine ›
- Isotretinoin ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amlodipine Besylate ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full 4-androsterone list.
4-androsterone References
The 3 sources that drive our 4-androsterone monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. 4-androsterone is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Anabolic Steroids and Other Appearance and Performance Enhancing Drugs (APEDs) — NIH National Institute on Drug Abuse Source
- Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
- DHEA — MedlinePlus Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking 4-androsterone and Tipiracil Hydrochloride, Trifluridine Together: Common Questions
Is it safe to take 4-androsterone with Tipiracil Hydrochloride, Trifluridine?
Should I take 4-androsterone and Tipiracil Hydrochloride, Trifluridine at the same time of day?
How was the 4-androsterone and Tipiracil Hydrochloride, Trifluridine combination checked?
Does 4-androsterone interact with any other medications?
Does Tipiracil Hydrochloride, Trifluridine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.