Drug & supplement interaction

4-androsterone + tislelizumab-jsgr

tislelizumab-jsgr brand name: Tevimbra.

No Known Interaction
The bottom line No known interaction

We found no known interaction between 4-androsterone and tislelizumab-jsgr in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

4-androsterone and tislelizumab-jsgr

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between tislelizumab-jsgr and 4-androsterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

4-androsterone safety at a glance

4-androsterone overall Use caution Prohormones can disrupt hormones, strain the liver, and affect cholesterol; safety is not well studied.
Pregnancy Avoid Androgenic hormones can harm a developing baby; do not use during pregnancy.
Breastfeeding Avoid Hormonal effects on a nursing infant are unknown and potentially harmful; avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining tislelizumab-jsgr and 4-androsterone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for tislelizumab-jsgr

Interactions in our licensed database are recorded against drug classes, not just single drug names. tislelizumab-jsgr is filed under 2 classifications — nephrotoxic drugs, hepatotoxic drugs. 4-androsterone has documented interactions with 1 drug class — the most serious being testosterone (moderate) — and none of tislelizumab-jsgr’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

4-androsterone Does Interact With Other Medications

4-androsterone has 8 moderate known drug interactions in our database — tislelizumab-jsgr isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against 4-androsterone

Covers the 2,830 medications we’ve checked against 4-androsterone. Pick one to open its full report.

What to actually watch for

What 4-androsterone Itself Has Been Linked To

This is not an interaction — nothing below involves tislelizumab-jsgr. It is the side-effect record for 4-androsterone on its own, from the licensed Natural Medicines monograph. If something new turns up after you add 4-androsterone, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Kidney problems / Liver problems Worth acting on Additional detail

    “There is insufficient information available about adverse effects associated with 4-androsterone. It is purported that 4-androsterone is metabolized to anabolic compounds. Therefore, in theory, there is concern that it might cause serious anabolic steroid-like side effects including stroke, kidney failure, and liver injury.”

    4-androsterone · Natural Medicines adverse-effect record, reported in kidney failure.

Everything above comes from the Natural Medicines adverse-effect record for 4-androsterone — expand a row for the licensed statement it rests on. We haven’t matched tislelizumab-jsgr to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for tislelizumab-jsgr.

Everything else you take

See Every Supplement That Interacts With tislelizumab-jsgr

This page covers 4-androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the tislelizumab-jsgr page lists 42 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Aristolochia (moderate).

By severity: 4 major · 37 moderate · 1 minor.

From our pharmacist’s overview on the tislelizumab-jsgr page

“Alcohol, even ordinary beer and wine, sits at the top of my concerns for anyone receiving tislelizumab-jsgr (Tevimbra), an immunotherapy for certain cancers of the esophagus and stomach. Drugs in this class can provoke immune attacks on the liver, and 38 of the 42 supplement ingredients on this page add liver stress of their own, so ne…”

Reviewed by 2 · Jul 18, 2026

Open the tislelizumab-jsgr interaction page

One more smart check

Taking 4-androsterone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 23 real supplement products containing 4-androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 4-androsterone. Even though 4-androsterone itself has no known interaction with tislelizumab-jsgr, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 4-androsterone and tislelizumab-jsgr Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 4-androsterone
Steady interest

#1,295 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication tislelizumab-jsgr
Top half

#783 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. 4-androsterone is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 4-androsterone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The 4-androsterone and tislelizumab-jsgr records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 4-androsterone

What is 4-androsterone?

  • Muscle building
  • Strength and athletic performance
  • Boosting testosterone
  • Bodybuilding cycles

4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human studies are very limited and it carries real risks like liver strain, hormone imbalance, and cholesterol changes. Its legal status is uncertain in many places, and it may cause a positive result on drug tests. We do not recommend it without close medical supervision, and it should be avoided in pregnancy and breastfeeding.

Synthetic steroidal compound (not a plant part) · Capsules, tablets, transdermal gels or creams, liquid drops

An interaction check asks whether these two react with each other — it does not ask whether 4-androsterone is a good idea for someone in your situation. Here is what our 4-androsterone record says about it on its own.

4-androsterone: dosing

There is no established, medically recommended dose for 4-androsterone. Doses used in bodybuilding come from product labels and informal community advice, not from rigorous clinical research.Because purity and strength can vary between products and the risks are significant, we cannot recommend a specific amount. Never assume that a higher dose is safer or more effective.

From our 4-androsterone monograph — the full record covers uses, side effects and every documented interaction.

Read the full 4-androsterone monograph & all interactions
Medication

About tislelizumab-jsgr

Most-Reported Side Effects for tislelizumab-jsgr

From FAERS, the FDA’s public side-effect reporting system (177 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Disease progression 64 reports
Malignant neoplasm progression 22 reports
Anemia 21 reports
Lymphadenopathy 19 reports
Thrombocytopenia 19 reports
Keep checking

Other Drugs & 4-androsterone

Browse every other medication we’ve checked against 4-androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
8Moderate
0Minor
2,821No known interaction
Moderate

8 interactions

No interaction 2,821 drugs checked — show the list
Evidence & sources

4-androsterone References

The 3 sources that drive our 4-androsterone monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. 4-androsterone is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Anabolic Steroids and Other Appearance and Performance Enhancing Drugs (APEDs) — NIH National Institute on Drug Abuse Source
  2. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  3. DHEA — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 4-androsterone and tislelizumab-jsgr Together: Common Questions

Is it safe to take 4-androsterone with tislelizumab-jsgr?
We do not list a known interaction between 4-androsterone and tislelizumab-jsgr. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the 4-androsterone and tislelizumab-jsgr combination checked?
Interactions in our licensed database are recorded against drug classes. tislelizumab-jsgr is filed under 2 classifications, and 4-androsterone has documented interactions with 1 drug class — none of tislelizumab-jsgr's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 4-androsterone interact with any other medications?
Yes. 4-androsterone has 8 documented drug interactions in our database — tislelizumab-jsgr is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does tislelizumab-jsgr interact with any supplements?
Yes. tislelizumab-jsgr has documented interactions with 42 supplements in our database — 4-androsterone is not one of them. The tislelizumab-jsgr interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About tislelizumab-jsgr and 4-androsterone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.