Acupressure + Duloxetine
Duloxetine brand names: Cymbalta, Drizalma Sprinkle, Irenka.
We found no known interaction between Acupressure and Duloxetine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Acupressure and Duloxetine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Duloxetine and Acupressure in our sources. This does not guarantee that the combination is completely free of risk — research on Acupressure alongside specific medications may be limited.
Worth understanding: our licensed dataset holds no drug-interaction record for Acupressure at all — not against Duloxetine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
Acupressure is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Acupressure safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Acupressure in Pregnancy & Breastfeeding
When used appropriately. Acupressure has been safely used during pregnancy in clinical trials without significant adverse effects.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Duloxetine Is Prescribed For, and What Acupressure Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Duloxetine is a prescription medicine with approved uses on its FDA label. Acupressure is a treatment: what follows is what researchers have looked at it for, and how strong that evidence is.
Duloxetine is prescribed for: Duloxetine delayed-release capsules treat major depressive disorder (MDD) and generalized anxiety disorder (GAD) in adults. They also manage diabetic peripheral neuropathic pain (nerve pain from diabetes), fibromyalgia, and chronic musculoskeletal pain (such as chronic low back pain and pain from osteoarthritis) in adults. GAD is also approved in pediatric patients 7 years and older for Cymbalta, Drizalma Sprinkle, and certain duloxetine delayed-release capsule products. Fibromyalgia is approved in patients 13 years and older for Cymbalta and some duloxetine delayed-release capsule products.
Read the rest of what Duloxetine is prescribed for
Age-specific approvals vary by product — follow your prescriber's guidance on which product is right for your age group.
Acupressure has been studied for:
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Back pain Natural Medicines rates the evidence for Acupressure: Possibly Effective Read what the research shows
Acupressure for back pain
Acupressure, administered via traditional and non-traditional methods, either alone or as an adjuvant treatment, seems to reduce chronic low back pain.
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Osteoarthritis studied, not established Acupressure has been studied for this. Natural Medicines rates the evidence: Possibly Ineffective Read what the research shows
Acupressure for osteoarthritis
Most research shows that manual acupressure does not improve pain or function in patients with knee osteoarthritis.
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Depression studied, not established Acupressure has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Acupressure for depression
Some clinical research suggests that acupressure may improve depression in various populations.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Duloxetine on your own; if you are taking Acupressure for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Acupressure or Duloxetine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Acupressure or Duloxetine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Is It Safe To Take Ignatia Amara (Ignatius Bean) With Cymbalta? ›
- Does Cymbalta (Duloxetine) Interact With Berberine? ›
- Does Apple Cider Vinegar Interact With Cymbalta? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Duloxetine
This page covers Acupressure only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Duloxetine page lists 132 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Lithium (major), Siberian Cocklebur (major) and Wine (major).
By severity: 5 major · 107 moderate · 20 minor.
Where Acupressure and Duloxetine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,173 of 1,452 supplements looked up here in the last 7 days
#47 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Acupressure reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Acupressure and Duloxetine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Acupressure
What is Acupressure?
- Nausea and vomiting
- Tension and stress
- Pain relief
- Headache
- Sleep problems
- Menstrual cramps
Acupressure is a hands-on technique that applies physical pressure to specific points on the body, based on traditional Chinese medicine. It is not an herb or supplement. It is generally low-risk when done gently, and the best evidence is for easing certain types of nausea, though results for most other uses are mixed or limited.
Not applicable — acupressure is a physical technique, not a plant or supplement · Finger or hand pressure on body points; acupressure wristbands; acupressure mats
An interaction check asks whether these two react with each other — it does not ask whether Acupressure is a good idea for someone in your situation. Here is what our Acupressure record says about it on its own.
Acupressure: dosing
There is no standardized "dose" for acupressure because it is a physical technique, not a pill or supplement. Sessions and pressure vary from person to person. A practitioner may press on a point for a number of seconds to a few minutes, sometimes repeating several times.If you use a product such as an acupressure wristband or mat, follow the directions on the label.
From our Acupressure monograph — the full record covers uses, side effects and every documented interaction.
About Duloxetine
What Is Duloxetine Used For?
Brand names: Cymbalta, Drizalma Sprinkle, Irenka
Duloxetine delayed-release capsules treat major depressive disorder (MDD) and generalized anxiety disorder (GAD) in adults. They also manage diabetic peripheral neuropathic pain (nerve pain from diabetes), fibromyalgia, and chronic musculoskeletal pain (such as chronic low back pain and pain from osteoarthritis) in adults.
GAD is also approved in pediatric patients 7 years and older for Cymbalta, Drizalma Sprinkle, and certain duloxetine delayed-release capsule products. Fibromyalgia is approved in patients 13 years and older for Cymbalta and some duloxetine delayed-release capsule products. Age-specific approvals vary by product — follow your prescriber's guidance on which product is right for your age group.
Other Drugs & Acupressure
Browse every other medication we’ve checked against Acupressure — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Acupressure against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Acupressure list.
Acupressure References
The 20 references that drive our Acupressure monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Jamigorn M, Phupong V. Acupressure and vitamin B6 to relieve nausea and vomiting in pregnancy: a randomized study. Arch Gynecol Obstet 2007;276:245-9. PubMed
- Helmreich, R. J., Shiao, S. Y., and Dune, L. S. Meta-analysis of acustimulation effects on nausea and vomiting in pregnant women. Explore (NY) 2006;2(5):412-421. PubMed
- de Aloysio, D. and Penacchioni, P. Morning sickness control in early pregnancy by Neiguan point acupressure. Obstet Gynecol 1992;80(5):852-854.
- Alkaissi, A., Ledin, T., Odkvist, L. M., and Kalman, S. P6 acupressure increases tolerance to nauseogenic motion stimulation in women at high risk for PONV. Can J Anaesth 2005;52(7):703-709. PubMed
- Steele, N. M., French, J., Gatherer-Boyles, J., Newman, S., and Leclaire, S. Effect of acupressure by Sea-Bands on nausea and vomiting of pregnancy. J Obstet Gynecol Neonatal Nurs 2001;30(1):61-70. DOI
- Werntoft, E. and Dykes, A. K. Effect of acupressure on nausea and vomiting during pregnancy. A randomized, placebo-controlled, pilot study. J Reprod Med 2001;46(9):835-839.
- O'Brien, B., Relyea, M. J., and Taerum, T. Efficacy of P6 acupressure in the treatment of nausea and vomiting during pregnancy. Am J Obstet Gynecol 1996;174(2):708-715. PubMed
- Hyde, E. Acupressure therapy for morning sickness. A controlled clinical trial. J Nurse Midwifery 1989;34(4):171-178. PubMed
- Shin, H. S., Song, Y. A., and Seo, S. Effect of Nei-Guan point (P6) acupressure on ketonuria levels, nausea and vomiting in women with hyperemesis gravidarum. J Adv Nurs 2007;59(5):510-519. PubMed
- Zhang CS, Xia J, Zhang AL, Yang AW, Thien F, Li Y, Wu D, Cai J, DaCosta C, Xue CC. Ear acupressure for perennial allergic rhinitis: A multicenter randomized controlled trial. Am J Rhinol Allergy. 2014 Jul-Aug;28(4):e152-7. doi: 10.2500/ajra.2014.28.4081. PubMed
- Vallim ETA, Marques ADCB, Coelho RCFP, Guimarães PRB, Felix JVC, Kalinke LP. Auricular acupressure in the quality of life of women with breast cancer: a randomized clinical trial. Rev Esc Enferm USP. 2019 Dec 2;53:e03525. doi: 10.1590/S1980-220X2018043603
- Tara F, Bahrami-Taghanaki H, Amini Ghalandarabad M, Zand-Kargar Z, Azizi H, Esmaily H, Azizi H. The Effect of Acupressure on the Severity of Nausea, Vomiting, and Retching in Pregnant Women: A Randomized Controlled Trial. Complement Med Res. 2020;27(4):25 PubMed
- Susana CT, Maria TML, Pilar DS, et al. Effectiveness of self-applied acupressure for cervical pain of benign origin (EDIDO-CUH): a randomized controlled clinical trial. Acupunct Med. 2020:964528420961398. PubMed
- Hamidzadeh A, Tavakol Z, Maleki M, et al. Effect of acupressure at the BL67 spot on the spontaneous rotation of fetus with breech presentation: A randomized controlled trial. Explore (NY) 2021. PubMed
- Chen SR, Hou WH, Lai JN, Kwong JSW, Lin PC. Effects of acupressure on anxiety: A systematic review and meta-analysis. J Integr Complement Med 2022;28(1):25-35. PubMed
- Israel L, Rotter G, Förster-Ruhrmann U, et al. Acupressure in patients with seasonal allergic rhinitis: a randomized controlled exploratory trial. Chin Med 2021;16(1):137. PubMed
- Lin J, Chen T, He J, Chung RC, Ma H, Tsang H. Impacts of acupressure treatment on depression: A systematic review and meta-analysis. World J Psychiatry 2022;12(1):169-186. PubMed
- Yeung WF, Yu BY, Chung KF, et al. Self-administered acupressure for insomnia disorder: A randomized controlled trial. Phytomedicine 2022;99:153993. PubMed
- Wu Y, Yang L, Zhong Z, et al. Auricular acupressure for hemodialysis patients with insomnia: A multicenter double-blind randomized sham-controlled trial. J Integr Complement Med 2022;28(4):339-348. PubMed
- Jiang ZF, Liu G, Sun XX, et al. Auricular acupressure for constipation in adults: a systematic review and meta-analysis. Front Physiol 2023;14:1257660. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Duloxetine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Duloxetine as a medicine that can lower these. This is not an interaction with Acupressure — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Duloxetine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Having Acupressure While Taking Duloxetine: Common Questions
Is it safe to have Acupressure while taking Duloxetine?
Do Acupressure and Duloxetine have any of the same side effects?
Are Acupressure and Duloxetine used for the same thing?
Does Duloxetine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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