Drug & supplement interaction

Acupressure + Azithromycin

Azithromycin brand names: Zithromax, Zmax, Azasite.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Acupressure and Azithromycin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Acupressure and Azithromycin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Azithromycin and Acupressure in our sources. This does not guarantee that the combination is completely free of risk — research on Acupressure alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Acupressure at all — not against Azithromycin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Acupressure is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Acupressure safety at a glance

Acupressure overall Generally safe Generally safe and low-risk when applied gently by a trained person or with proper instruction.
Pregnancy Possibly Safe When used appropriately. Acupressure has been safely used during pregnancy in clinical trials without significant adverse effects. Read the full pregnancy detail
Breastfeeding Possibly Safe When used appropriately. Acupressure has been safely used during pregnancy in clinical trials without significant adverse effects. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Azithromycin and Acupressure? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Acupressure and Azithromycin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so having Acupressure while taking the medicine can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas / Nausea reported in 5.8% of FDA reports for Azithromycin Additional detail

    Acupressure

    “Nausea, bloating, and stomachache have been reported rarely in clinical research.”

    Acupressure · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 110307. Israel L, Rotter G, Förster-Ruhrmann U, et al. Acupressure in patients with seasonal allergic rhinitis: a randomized controlled exploratory trial. Chin Med 2021;16(1):137. PubMed
    2. 110311. Yeung WF, Yu BY, Chung KF, et al. Self-administered acupressure for insomnia disorder: A randomized controlled trial. Phytomedicine 2022;99:153993. PubMed

    Azithromycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Azithromycin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A fast or pounding heartbeat / Low blood pressure Additional detail

    Acupressure

    “Hypotension and palpitations have been reported rarely in clinical trials.”

    Acupressure · Natural Medicines adverse-effect record, reported in hypotension.

    4 sources cited
    1. 105120. Susana CT, Maria TML, Pilar DS, et al. Effectiveness of self-applied acupressure for cervical pain of benign origin (EDIDO-CUH): a randomized controlled clinical trial. Acupunct Med. 2020:964528420961398. PubMed
    2. 110296. Chen SR, Hou WH, Lai JN, Kwong JSW, Lin PC. Effects of acupressure on anxiety: A systematic review and meta-analysis. J Integr Complement Med 2022;28(1):25-35. PubMed
    3. 110308. Lin J, Chen T, He J, Chung RC, Ma H, Tsang H. Impacts of acupressure treatment on depression: A systematic review and meta-analysis. World J Psychiatry 2022;12(1):169-186. PubMed
    4. 110313. Wu Y, Yang L, Zhong Z, et al. Auricular acupressure for hemodialysis patients with insomnia: A multicenter double-blind randomized sham-controlled trial. J Integr Complement Med 2022;28(4):339-348. PubMed

    Azithromycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Azithromycin. Read the label on DailyMed ›

  • Itching Additional detail

    Acupressure

    “Skin discomfort, such as bruising, itching, irritation, pressure, and inflammation at the site of application has been reported in people using both acupressure and sham acupressure.”

    Acupressure · Natural Medicines adverse-effect record, reported in pruritus.

    5 sources cited
    1. 103398. Zhang CS, Xia J, Zhang AL, Yang AW, Thien F, Li Y, Wu D, Cai J, DaCosta C, Xue CC. Ear acupressure for perennial allergic rhinitis: A multicenter randomized controlled trial. Am J Rhinol Allergy. 2014 Jul-Aug;28(4):e152-7. doi: 10.2500/ajra.2014.28.4081. PubMed
    2. 103407. Vallim ETA, Marques ADCB, Coelho RCFP, Guimarães PRB, Felix JVC, Kalinke LP. Auricular acupressure in the quality of life of women with breast cancer: a randomized clinical trial. Rev Esc Enferm USP. 2019 Dec 2;53:e03525. doi: 10.1590/S1980-220X2018043603
    3. 105120. Susana CT, Maria TML, Pilar DS, et al. Effectiveness of self-applied acupressure for cervical pain of benign origin (EDIDO-CUH): a randomized controlled clinical trial. Acupunct Med. 2020:964528420961398. PubMed
    4. 110311. Yeung WF, Yu BY, Chung KF, et al. Self-administered acupressure for insomnia disorder: A randomized controlled trial. Phytomedicine 2022;99:153993. PubMed
    5. 114084. Jiang ZF, Liu G, Sun XX, et al. Auricular acupressure for constipation in adults: a systematic review and meta-analysis. Front Physiol 2023;14:1257660. PubMed

    Azithromycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Azithromycin. Read the label on DailyMed ›

  • Dizziness / Headache Additional detail

    Acupressure

    “Headache and dizziness have been reported in people using both acupressure and sham acupressure.”

    Acupressure · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 103398. Zhang CS, Xia J, Zhang AL, Yang AW, Thien F, Li Y, Wu D, Cai J, DaCosta C, Xue CC. Ear acupressure for perennial allergic rhinitis: A multicenter randomized controlled trial. Am J Rhinol Allergy. 2014 Jul-Aug;28(4):e152-7. doi: 10.2500/ajra.2014.28.4081. PubMed
    2. 103407. Vallim ETA, Marques ADCB, Coelho RCFP, Guimarães PRB, Felix JVC, Kalinke LP. Auricular acupressure in the quality of life of women with breast cancer: a randomized clinical trial. Rev Esc Enferm USP. 2019 Dec 2;53:e03525. doi: 10.1590/S1980-220X2018043603
    3. 105120. Susana CT, Maria TML, Pilar DS, et al. Effectiveness of self-applied acupressure for cervical pain of benign origin (EDIDO-CUH): a randomized controlled clinical trial. Acupunct Med. 2020:964528420961398. PubMed
    4. 110296. Chen SR, Hou WH, Lai JN, Kwong JSW, Lin PC. Effects of acupressure on anxiety: A systematic review and meta-analysis. J Integr Complement Med 2022;28(1):25-35. PubMed
    5. 110308. Lin J, Chen T, He J, Chung RC, Ma H, Tsang H. Impacts of acupressure treatment on depression: A systematic review and meta-analysis. World J Psychiatry 2022;12(1):169-186. PubMed
    6. 110311. Yeung WF, Yu BY, Chung KF, et al. Self-administered acupressure for insomnia disorder: A randomized controlled trial. Phytomedicine 2022;99:153993. PubMed

    Azithromycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Azithromycin. Read the label on DailyMed ›

Reported for Acupressure but not commonly for Azithromycin: bleeding or bruising.

Effects for Azithromycin come from the ADVERSE REACTIONS section of its FDA label; effects for Acupressure come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 59,712 voluntary FDA FAERS reports for Azithromycin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Acupressure in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Safe

When used appropriately. Acupressure has been safely used during pregnancy in clinical trials without significant adverse effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Acupressure or Azithromycin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Acupressure or Azithromycin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Azithromycin

This page covers Acupressure only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Azithromycin page lists 92 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 71 moderate · 13 minor.

From our pharmacist’s overview on the Azithromycin page

“A five-day Z-Pak for a sinus or chest infection seems too brief to fuss over, but azithromycin (Zithromax, Zmax) deserves genuine caution around supplements, and the eight major-rated entries on this list are the ones to understand first. Most of those involve the heart.”

Reviewed by 2 · Jul 18, 2026

Open the Azithromycin interaction page

How much people look this up

Where Acupressure and Azithromycin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Acupressure
Steady interest

#1,173 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Azithromycin
Top 5%

#60 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Acupressure reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Acupressure and Azithromycin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Treatment approach

About Acupressure

What is Acupressure?

  • Nausea and vomiting
  • Tension and stress
  • Pain relief
  • Headache
  • Sleep problems
  • Menstrual cramps

Acupressure is a hands-on technique that applies physical pressure to specific points on the body, based on traditional Chinese medicine. It is not an herb or supplement. It is generally low-risk when done gently, and the best evidence is for easing certain types of nausea, though results for most other uses are mixed or limited.

Not applicable — acupressure is a physical technique, not a plant or supplement · Finger or hand pressure on body points; acupressure wristbands; acupressure mats

An interaction check asks whether these two react with each other — it does not ask whether Acupressure is a good idea for someone in your situation. Here is what our Acupressure record says about it on its own.

Acupressure: dosing

There is no standardized "dose" for acupressure because it is a physical technique, not a pill or supplement. Sessions and pressure vary from person to person. A practitioner may press on a point for a number of seconds to a few minutes, sometimes repeating several times.If you use a product such as an acupressure wristband or mat, follow the directions on the label.

From our Acupressure monograph — the full record covers uses, side effects and every documented interaction.

Read the full Acupressure monograph & all interactions
Medication

About Azithromycin

What Is Azithromycin Used For?

Brand names: Zithromax, Zmax, Azasite

  • Azithromycin is used to treat certain bacterial infections, such as bronchitis; pneumonia; sexually transmitted diseases (STD); and infections of the ears, lungs, sinuses, skin, throat, and reproductive organs. Azithromycin also is used to treat or prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)]. Azithromycin is in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria.

  • Antibiotics such as azithromycin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Most-Reported Side Effects for Azithromycin

From FAERS, the FDA’s public side-effect reporting system (59,712 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 4,651 reports
Nausea 3,461 reports
Pneumonia 3,225 reports
Cough 3,120 reports
Drug hypersensitivity 2,991 reports
See full Azithromycin drug information
Keep checking

Other Drugs & Acupressure

Browse every other medication we’ve checked against Acupressure — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Acupressure References

The 20 references that drive our Acupressure monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Jamigorn M, Phupong V. Acupressure and vitamin B6 to relieve nausea and vomiting in pregnancy: a randomized study. Arch Gynecol Obstet 2007;276:245-9. PubMed
  2. Helmreich, R. J., Shiao, S. Y., and Dune, L. S. Meta-analysis of acustimulation effects on nausea and vomiting in pregnant women. Explore (NY) 2006;2(5):412-421. PubMed
  3. de Aloysio, D. and Penacchioni, P. Morning sickness control in early pregnancy by Neiguan point acupressure. Obstet Gynecol 1992;80(5):852-854.
  4. Alkaissi, A., Ledin, T., Odkvist, L. M., and Kalman, S. P6 acupressure increases tolerance to nauseogenic motion stimulation in women at high risk for PONV. Can J Anaesth 2005;52(7):703-709. PubMed
  5. Steele, N. M., French, J., Gatherer-Boyles, J., Newman, S., and Leclaire, S. Effect of acupressure by Sea-Bands on nausea and vomiting of pregnancy. J Obstet Gynecol Neonatal Nurs 2001;30(1):61-70. DOI
  6. Werntoft, E. and Dykes, A. K. Effect of acupressure on nausea and vomiting during pregnancy. A randomized, placebo-controlled, pilot study. J Reprod Med 2001;46(9):835-839.
  7. O'Brien, B., Relyea, M. J., and Taerum, T. Efficacy of P6 acupressure in the treatment of nausea and vomiting during pregnancy. Am J Obstet Gynecol 1996;174(2):708-715. PubMed
  8. Hyde, E. Acupressure therapy for morning sickness. A controlled clinical trial. J Nurse Midwifery 1989;34(4):171-178. PubMed
  9. Shin, H. S., Song, Y. A., and Seo, S. Effect of Nei-Guan point (P6) acupressure on ketonuria levels, nausea and vomiting in women with hyperemesis gravidarum. J Adv Nurs 2007;59(5):510-519. PubMed
  10. Zhang CS, Xia J, Zhang AL, Yang AW, Thien F, Li Y, Wu D, Cai J, DaCosta C, Xue CC. Ear acupressure for perennial allergic rhinitis: A multicenter randomized controlled trial. Am J Rhinol Allergy. 2014 Jul-Aug;28(4):e152-7. doi: 10.2500/ajra.2014.28.4081. PubMed
  11. Vallim ETA, Marques ADCB, Coelho RCFP, Guimarães PRB, Felix JVC, Kalinke LP. Auricular acupressure in the quality of life of women with breast cancer: a randomized clinical trial. Rev Esc Enferm USP. 2019 Dec 2;53:e03525. doi: 10.1590/S1980-220X2018043603
  12. Tara F, Bahrami-Taghanaki H, Amini Ghalandarabad M, Zand-Kargar Z, Azizi H, Esmaily H, Azizi H. The Effect of Acupressure on the Severity of Nausea, Vomiting, and Retching in Pregnant Women: A Randomized Controlled Trial. Complement Med Res. 2020;27(4):25 PubMed
  13. Susana CT, Maria TML, Pilar DS, et al. Effectiveness of self-applied acupressure for cervical pain of benign origin (EDIDO-CUH): a randomized controlled clinical trial. Acupunct Med. 2020:964528420961398. PubMed
  14. Hamidzadeh A, Tavakol Z, Maleki M, et al. Effect of acupressure at the BL67 spot on the spontaneous rotation of fetus with breech presentation: A randomized controlled trial. Explore (NY) 2021. PubMed
  15. Chen SR, Hou WH, Lai JN, Kwong JSW, Lin PC. Effects of acupressure on anxiety: A systematic review and meta-analysis. J Integr Complement Med 2022;28(1):25-35. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Having Acupressure While Taking Azithromycin: Common Questions

Is it safe to have Acupressure while taking Azithromycin?
We do not list a known interaction between Acupressure and Azithromycin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Acupressure and Azithromycin have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Azithromycin interact with any supplements?
Yes. Azithromycin has documented interactions with 92 supplements in our database — Acupressure is not one of them. The Azithromycin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Azithromycin and Acupressure?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.