Drug & supplement interaction

Alpha-ketoglutarate (akg) + Aluminum Hydroxide

Aluminum Hydroxide brand names: Amphojel, Gaviscon, Alu-Cap.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Alpha-ketoglutarate (akg) and Aluminum Hydroxide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Alpha-ketoglutarate (akg) and Aluminum Hydroxide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Aluminum Hydroxide and Alpha-ketoglutarate (akg) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Alpha-ketoglutarate (akg) at all — not against Aluminum Hydroxide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Alpha-ketoglutarate (akg) safety at a glance

Alpha-ketoglutarat... overall Use caution Generally tolerated in short-term studies, but long-term human safety data are limited.
Pregnancy Avoid Not enough safety data, so avoid use during pregnancy.
Breastfeeding Avoid Not enough safety data, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Aluminum Hydroxide and Alpha-ketoglutarate (akg)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
From our Q&A

Questions About Alpha-ketoglutarate (akg) or Aluminum Hydroxide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Alpha-ketoglutarate (akg) or Aluminum Hydroxide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Aluminum Hydroxide

This page covers Alpha-ketoglutarate (akg) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aluminum Hydroxide page lists 35 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Calcium (moderate), Cinchona (moderate), Coffee Charcoal (moderate) and European Mandrake (moderate).

By severity: 1 major · 14 moderate · 20 minor.

From our pharmacist’s overview on the Aluminum Hydroxide page

“An antacid sounds harmless, and that is exactly why the supplement interactions with aluminum hydroxide (Amphojel, Gaviscon) deserve real attention before you combine it with much of anything. The most serious entry is activated charcoal, which can soak up many medications in the gut and sharply cut how much of them your body actually…”

Reviewed by 2 · Jul 18, 2026

Open the Aluminum Hydroxide interaction page

How much people look this up

Where Alpha-ketoglutarate (akg) and Aluminum Hydroxide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alpha-ketoglutarate (akg)
Steady interest

#1,340 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aluminum Hydroxide
Top half

#807 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Alpha-ketoglutarate (akg) is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alpha-ketoglutarate (akg) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Alpha-ketoglutarate (akg) and Aluminum Hydroxide records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Alpha-ketoglutarate (akg)

What is Alpha-ketoglutarate (akg)?

Alpha-ketoglutarate (akg)
  • Anti-aging and longevity support
  • Athletic performance and recovery
  • Muscle building
  • Bone health
  • General metabolic and energy support

Alpha-ketoglutarate (AKG) is a natural molecule in the body's energy-making (Krebs) cycle that is now sold as a supplement, mainly marketed for longevity, exercise, and muscle support. Most human evidence is limited or early, and many popular claims rest on lab or animal studies, so benefits are not well proven. Talk with your pharmacist or doctor before starting it, especially if you are pregnant, breastfeeding, or have a health condition.

Not applicable (a naturally occurring metabolic molecule, made synthetically for supplements) · Capsules, tablets, powders; often as calcium alpha-ketoglutarate (Ca-AKG), arginine alpha-ketoglutarate (AAKG), or ornithine alpha-ketoglutarate (OKG)

An interaction check asks whether these two react with each other — it does not ask whether Alpha-ketoglutarate (akg) is a good idea for someone in your situation. Here is what our Alpha-ketoglutarate (akg) record says about it on its own.

Alpha-ketoglutarate (akg): dosing

There is no official, established dose of AKG for any health condition. Doses used in studies have varied widely depending on the form (calcium AKG, arginine AKG, or ornithine AKG) and the purpose.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Alpha-ketoglutarate (akg) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Alpha-ketoglutarate (akg) monograph & all interactions
Medication

About Aluminum Hydroxide

What Is Aluminum Hydroxide Used For?

Brand names: Amphojel, Gaviscon, Alu-Cap

Aluminum hydroxide is used in two distinct ways depending on the product. The oral liquid form relieves heartburn, acid indigestion, and sour stomach.

ProCure DryDrox, a topical ointment, is used on the skin to dry the oozing and weeping caused by poison ivy, oak, and sumac reactions.

Most-Reported Side Effects for Aluminum Hydroxide

From FAERS, the FDA’s public side-effect reporting system (8,103 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 534 reports
Diarrhea 504 reports
Vomiting 497 reports
Chronic kidney disease 478 reports
Dyspnea 476 reports
See full Aluminum Hydroxide drug information
Keep checking

Other Drugs & Alpha-ketoglutarate (akg)

Browse every other medication we’ve checked against Alpha-ketoglutarate (akg) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Alpha-ketoglutarate (akg) References

The 2 sources that drive our Alpha-ketoglutarate (akg) monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Alpha-ketoglutarate (akg) is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Arginine — NIH Office of Dietary Supplements / MedlinePlus Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Alpha-ketoglutarate (akg) and Aluminum Hydroxide Together: Common Questions

Is it safe to take Alpha-ketoglutarate (akg) with Aluminum Hydroxide?
We do not list a known interaction between Alpha-ketoglutarate (akg) and Aluminum Hydroxide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Aluminum Hydroxide interact with any supplements?
Yes. Aluminum Hydroxide has documented interactions with 35 supplements in our database — Alpha-ketoglutarate (akg) is not one of them. The Aluminum Hydroxide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aluminum Hydroxide and Alpha-ketoglutarate (akg)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.