Drug & supplement interaction

American Chestnut + Piroxicam

Piroxicam brand names: Feldene, Feldene Gel.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between American Chestnut and Piroxicam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

American Chestnut and Piroxicam

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Piroxicam and American Chestnut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for American Chestnut at all — not against Piroxicam, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

American Chestnut safety at a glance

American Chestnut overall Use caution Little modern safety data exists, and the high tannin content can irritate the stomach or affect nutrient absorption.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Piroxicam and American Chestnut? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Piroxicam’s Own FDA Label Lists

This is not an interaction — none of it involves American Chestnut. These are the most notable effects listed in the ADVERSE REACTIONS section of Piroxicam’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Bleeding in the gut Worth acting on
  • High potassium Worth acting on
  • Low blood sugar Worth acting on
  • A heart attack Worth acting on
  • Hallucinations Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Heart failure Worth acting on
  • An allergic reaction Worth acting on mentioned in 15.4% of FDA reports for Piroxicam

Showing the 10 most notable of 59 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Piroxicam. Read the label on DailyMed › Where a percentage is shown, it is the share of 6,275 voluntary FDA FAERS reports for Piroxicam that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. American Chestnut’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no American Chestnut side to compare — that is a limit of the record, not a statement that American Chestnut has no side effects.

From our Q&A

Questions About American Chestnut or Piroxicam

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers American Chestnut or Piroxicam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Piroxicam

This page covers American Chestnut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Piroxicam page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 242 moderate · 36 minor.

From our pharmacist’s overview on the Piroxicam page

“Piroxicam (Feldene) is a potent, long-acting NSAID for arthritis pain, and since it already carries real stomach-bleeding risk on its own, my honest read is that this page calls for genuine caution rather than a quick skim. Most of the 285 interacting supplements share a single problem: they thin the blood or blunt platelets, stacking…”

Reviewed by 2 · Jul 18, 2026

Open the Piroxicam interaction page

One more smart check

Taking American Chestnut as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing American Chestnut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides American Chestnut. Even though American Chestnut itself has no known interaction with Piroxicam, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where American Chestnut and Piroxicam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Chestnut
Steady interest

#1,251 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Piroxicam
Top half

#1,318 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. American Chestnut is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Chestnut reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The American Chestnut and Piroxicam records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About American Chestnut

What is American Chestnut?

American Chestnut
  • Cough and whooping cough
  • Respiratory ailments
  • Sore throat (topical/gargle)
  • Astringent for mucous membranes
  • Traditional tonic and sedative

American chestnut leaves and bark have a long history of folk use for coughs and respiratory complaints, mainly because of their tannin content, which has an astringent effect. However, there is very little modern scientific evidence to support these uses, and safety has not been well studied, so it should be used cautiously and discussed with a healthcare professional.

Castanea dentata · Fagaceae · Leaves and bark · Tea, liquid extract, dried leaf

An interaction check asks whether these two react with each other — it does not ask whether American Chestnut is a good idea for someone in your situation. Here is what our American Chestnut record says about it on its own.

American Chestnut: dosing

There is no standardized or well-established dose for American chestnut. Traditional use involved teas or extracts made from the dried leaves, but the amount of active compounds can vary widely depending on the product and how it is prepared.If you choose to use a product, follow the directions on the label and do not exceed them.

From our American Chestnut monograph — the full record covers uses, side effects and every documented interaction.

Read the full American Chestnut monograph & all interactions
Medication

About Piroxicam

What Is Piroxicam Used For?

Brand names: Feldene, Feldene Gel

Piroxicam capsules are used to relieve pain, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis. It targets inflammation at the source to help improve day-to-day comfort and movement.

Piroxicam is not a cure for either condition — it manages symptoms. Your prescriber will weigh the benefits against the risks and aim for the lowest effective dose for the shortest time needed.

Most-Reported Side Effects for Piroxicam

From FAERS, the FDA’s public side-effect reporting system (6,347 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug hypersensitivity 980 reports
Rash 921 reports
Arthralgia 915 reports
Rheumatoid arthritis 856 reports
Fatigue 855 reports
See full Piroxicam drug information
Keep checking

Other Drugs & American Chestnut

Browse every other medication we’ve checked against American Chestnut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked American Chestnut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full American Chestnut list.

See the full American Chestnut interactions page
See every supplement checked against Piroxicam, ranked by severity
Evidence & sources

American Chestnut References

The 2 sources that drive our American Chestnut monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. American Chestnut is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Tannins — MedlinePlus Source
  2. Herbs at a Glance — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking American Chestnut and Piroxicam Together: Common Questions

Is it safe to take American Chestnut with Piroxicam?
We do not list a known interaction between American Chestnut and Piroxicam. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Piroxicam interact with any supplements?
Yes. Piroxicam has documented interactions with 285 supplements in our database — American Chestnut is not one of them. The Piroxicam interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

American Chestnut monograph Uses, safety profile, and every drug interaction in one place Piroxicam drug information The full plain-English guide to this medication Piroxicam supplement interactions Every supplement checked against Piroxicam, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Piroxicam and American Chestnut?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.