Drug & supplement interaction

Androstenediol + Apraclonidine

Apraclonidine brand name: Iopidine.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Androstenediol and Apraclonidine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Androstenediol and Apraclonidine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Apraclonidine and Androstenediol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Androstenediol safety at a glance

Androstenediol overall Avoid It is a controlled anabolic steroid with hormonal risks and is best avoided unless prescribed and supervised.
Pregnancy Avoid Androgen-like hormones can harm a developing baby, so it should not be used during pregnancy.
Breastfeeding Avoid Hormonal effects on a nursing infant are unknown, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Apraclonidine and Androstenediol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Apraclonidine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Apraclonidine is filed under 2 classifications — alpha-adrenergic agonists, oral drugs. Androstenediol has documented interactions with 2 drug classes — the most serious being estrogens (moderate) and testosterone (moderate) — and none of Apraclonidine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Androstenediol Does Interact With Other Medications

Androstenediol has 47 moderate known drug interactions in our database — Apraclonidine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 47 No known interaction 2,783 (incl. Apraclonidine)
Taking anything else?

Check Another of Your Medications Against Androstenediol

Covers the 2,830 medications we’ve checked against Androstenediol. Pick one to open its full report.

What to actually watch for

What Apraclonidine’s Own FDA Label Lists

This is not an interaction — none of it involves Androstenediol. These are the most notable effects listed in the ADVERSE REACTIONS section of Apraclonidine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 7 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Wheezing Worth acting on
  • An irregular heartbeat Worth acting on
  • Shortness of breath Worth acting on mentioned in 4.7% of FDA reports for Apraclonidine
  • Chest pain Worth acting on
  • Low mood Worth acting on
  • An allergic reaction Worth acting on
  • Dry eyes
  • Blurred vision mentioned in 5.7% of FDA reports for Apraclonidine
  • Dry mouth mentioned in 4.7% of FDA reports for Apraclonidine

Showing the 10 most notable of 25 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Apraclonidine. Read the label on DailyMed › Where a percentage is shown, it is the share of 106 voluntary FDA FAERS reports for Apraclonidine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Androstenediol’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Androstenediol side to compare — that is a limit of the record, not a statement that Androstenediol has no side effects.

Everything else you take

See Every Supplement That Interacts With Apraclonidine

This page covers Androstenediol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Apraclonidine page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Butcher's Broom (moderate), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 1 major · 8 moderate · 9 minor.

From our pharmacist’s overview on the Apraclonidine page

“Apraclonidine (Iopidine) is an eye drop that lowers pressure inside the eye, most often around laser procedures, and its interaction list deserves a careful read rather than a shrug. Of the 18 supplement and herbal ingredients on file, only one rates major, and that one is activated charcoal, which binds many drugs and can reduce their…”

Reviewed by 2 · Jul 18, 2026

Open the Apraclonidine interaction page

How much people look this up

Where Androstenediol and Apraclonidine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Androstenediol
Steady interest

#788 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Apraclonidine
Steady interest

#2,015 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Androstenediol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Androstenediol and Apraclonidine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Androstenediol

What is Androstenediol?

Androstenediol
  • Boosting testosterone
  • Building muscle and strength
  • Enhancing athletic performance
  • Anti-aging / general vitality
  • Bodybuilding cutting or bulking cycles

Androstenediol is a prohormone (a precursor the body can convert into testosterone and other hormones) marketed to raise testosterone and build muscle, but solid human evidence for these benefits is lacking and it carries real hormonal risks. In the United States it is a Schedule III controlled substance and is banned in most competitive sports. Talk with a doctor or pharmacist before considering any product containing it.

Not a plant; a steroid hormone (prohormone) made synthetically or naturally in the body · Capsules, tablets, sublingual tablets, sprays (sold as 'prohormone' supplements)

An interaction check asks whether these two react with each other — it does not ask whether Androstenediol is a good idea for someone in your situation. Here is what our Androstenediol record says about it on its own.

Androstenediol: dosing

There is no established safe or effective dose of androstenediol, and because it is a controlled substance, it is not a routine over-the-counter supplement. The body of research does not support a recommended amount.If you are considering any product that contains it, do not rely on label claims.

From our Androstenediol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Androstenediol monograph & all interactions
Medication

About Apraclonidine Ophthalmic

What Is Apraclonidine Ophthalmic Used For?

Brand name: Iopidine

Apraclonidine ophthalmic solution 0.5% is indicated as a short-term add-on therapy for patients with glaucoma who are already on the maximum tolerated medical treatment but still need additional reduction in intraocular pressure (IOP — the pressure inside the eye). It may be used to help delay the need for surgery while other options are explored.

It's worth knowing that if you're already using two aqueous-suppressing drugs (medicines that reduce fluid production in the eye) — such as a beta-blocker combined with a carbonic anhydrase inhibitor — adding apraclonidine may not provide much additional benefit, since it works by the same mechanism.

Most-Reported Side Effects for Apraclonidine

From FAERS, the FDA’s public side-effect reporting system (106 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Somnolence 7 reports
Eyelid ptosis 6 reports
Vision blurred 6 reports
Constipation 5 reports
Dry mouth 5 reports
See full Apraclonidine Ophthalmic drug information
Keep checking

Other Drugs & Androstenediol

Browse every other medication we’ve checked against Androstenediol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
47Moderate
0Minor
2,782No known interaction
47 Moderate 2,782 No interaction
Moderate

47 interactions

No interaction 2,782 drugs checked — show the list

We also checked Androstenediol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,782 medications checked with no known interaction — see the full Androstenediol list.

See the full Androstenediol interactions page
See every supplement checked against Apraclonidine, ranked by severity
Evidence & sources

Androstenediol References

The 3 references that drive our Androstenediol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
  2. Brown GA, Martini ER, Roberts BS, et al. Acute hormonal response to sublingual androstenediol intake in young men. J Appl Physiol 2002;92:142-6. PubMed
  3. Battista, V., Combs, J., and Warme, W. J. Asynchronous bilateral achilles tendon ruptures and androstenediol use. Am J Sports Med 2003;31(6):1007-1009. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Androstenediol and Apraclonidine Together: Common Questions

Is it safe to take Androstenediol with Apraclonidine?
We do not list a known interaction between Androstenediol and Apraclonidine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Androstenediol and Apraclonidine combination checked?
Interactions in our licensed database are recorded against drug classes. Apraclonidine is filed under 2 classifications, and Androstenediol has documented interactions with 2 drug classes — none of Apraclonidine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Androstenediol interact with any other medications?
Yes. Androstenediol has 47 documented drug interactions in our database — Apraclonidine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Apraclonidine interact with any supplements?
Yes. Apraclonidine has documented interactions with 18 supplements in our database — Androstenediol is not one of them. The Apraclonidine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Androstenediol monograph Uses, safety profile, and every drug interaction in one place Apraclonidine Ophthalmic drug information The full plain-English guide to this medication Apraclonidine supplement interactions Every supplement checked against Apraclonidine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Apraclonidine and Androstenediol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.