Androstenediol - Conjugated Estrogens, Meprobamate Interaction
Herbal: Androstenediol
Drug: Conjugated Estrogens, Meprobamate
Brand names:
PMB 200, PMB 400

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 11, 2025
Interaction Details
Conjugated Estrogens, Meprobamate is classified as belonging to the following category: Estrogens
Androstenediol is a precursor to estrogen and can increase levels of estradiol and estrone. There is some concern that taking androstenediol with estrogens might increase estrogenic effects and potential side effects. However, androstenediol is converted to estrogen in low estrogen environments. Patients who are taking supplemental estrogen do not have low estrogen levels. Therefore, androstenediol might not be converted to estrogen in these patients. It is unclear how this might alter the effects and side effects of androstenediol. Until more is known, use with caution or avoid using with estrogen-containing drugs. Some of these drugs include CombiPatch, Estraderm Transdermal, Kestrone, Vivelle Transdermal, and others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
- Brown GA, Martini ER, Roberts BS, et al. Acute hormonal response to sublingual androstenediol intake in young men. J Appl Physiol 2002;92:142-6.
Androstenediol Overview

Androstenediol - More Interactions
Androstenediol interacts with 47 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.