Anise - Codeine Phosphate, Pseudoephedrine Interaction
Herbal: Anise
Also Known As: Pimpinella anisum, Anis, Anís, Anis Vert, Aniseed, Anise Essential Oil, Anise Oil, Anisi Fructus, Graine d'Anis Vert, Green Anise, Huile Essentielle d'Anis, Phytoestrogen, Phyto-Œstrogène, Pinella, Semen Anisi, Shatpushpa, Sweet Cumin
Drug: Codeine Phosphate, Pseudoephedrine
Brand names:
Nucofed, Kg Fed

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Codeine Phosphate, Pseudoephedrine is classified as belonging to the following category: Codeine
Theoretically, anise oil might increase the effects and adverse effects of codeine.
Animal research shows that anise oil increases the analgesic effects of codeine, possibly by inducing its phase I metabolism and increasing conversion to morphine. Whether this interaction occurs in humans is unclear.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Samojlik I, Mijatovic V, Petkovic S, et al. The influence of essential oil of aniseed (Pimpinella anisum, L.) on drug effects on the central nervous system. Fitoterapia 2012;83:1466-73.
Anise Overview

Anise - More Interactions
Anise interacts with 243 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.