Drug & supplement interaction

Arrowroot + Memantine

Memantine brand name: Ebixa.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Arrowroot and Memantine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Arrowroot and Memantine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Memantine and Arrowroot in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Arrowroot at all — not against Memantine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Arrowroot safety at a glance

Arrowroot overall Generally safe Arrowroot starch is widely eaten as food and is generally well tolerated in normal amounts.
Pregnancy Possibly Safe When used in amounts found in foods. There is insufficient reliable information available about the safety of larger amounts used during pregnancy and lactation... Read the full pregnancy detail
Breastfeeding Possibly Safe When used in amounts found in foods. There is insufficient reliable information available about the safety of larger amounts used during pregnancy and lactation... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Memantine and Arrowroot? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Arrowroot and Memantine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Constipation Additional detail

    Arrowroot

    “Orally, arrowroot starch from the root or rhizome is well tolerated when used in the amounts found in foods (12). There is a limited amount of information available about the adverse effects of arrowroot when used in medicinal amounts. In one clinical trial, it was reported to cause dyspepsia, constipation, and dark stools (12,32448).”

    Arrowroot · Natural Medicines adverse-effect record, reported in constipation.

    2 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 32448. Cooke, C., Carr, I., Abrams, K., and Mayberry, J. Arrowroot as a treatment for diarrhoea in irritable bowel syndrome patients: a pilot study. Arq Gastroenterol. 2000;37(1):20-24. PubMed

    “Orally, arrowroot has been reported to cause dyspepsia, constipation, and dark stools in one clinical trial.”

    Arrowroot · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 32448. Cooke, C., Carr, I., Abrams, K., and Mayberry, J. Arrowroot as a treatment for diarrhoea in irritable bowel syndrome patients: a pilot study. Arq Gastroenterol. 2000;37(1):20-24. PubMed

    Memantine

    Listed in the ADVERSE REACTIONS section of the FDA label for Memantine. Read the label on DailyMed ›

Reported for Arrowroot but not commonly for Memantine: stomach upset.

Effects for Memantine come from the ADVERSE REACTIONS section of its FDA label; effects for Arrowroot come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Arrowroot in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Safe

When used in amounts found in foods. There is insufficient reliable information available about the safety of larger amounts used during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Memantine

This page covers Arrowroot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Memantine page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Threonine (major), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 2 major · 7 moderate · 9 minor.

Open the Memantine interaction page

One more smart check

Taking Arrowroot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 28 real supplement products containing Arrowroot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Arrowroot. Even though Arrowroot itself has no known interaction with Memantine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Arrowroot and Memantine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Arrowroot
Top half

#475 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Memantine
Steady interest

#1,625 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Arrowroot reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Arrowroot and Memantine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Arrowroot

What is Arrowroot?

Arrowroot
  • Diarrhea
  • Irritable bowel syndrome (IBS) symptoms
  • Digestive upset
  • Gluten-free thickener/food ingredient
  • Soothing skin and cosmetics

Arrowroot is a starch made from the roots of Maranta arundinacea and is mainly used as a gentle, easy-to-digest thickening agent in food. Some people use it for diarrhea and digestive discomfort, but solid human evidence for these health benefits is limited. As a food it is generally well tolerated, but talk with your pharmacist or doctor before using it to treat a medical condition.

Maranta arundinacea · Marantaceae · Rhizomes (roots), processed into starch · Powder (starch), flour, capsules, food thickener, cosmetic ingredient

An interaction check asks whether these two react with each other — it does not ask whether Arrowroot is a good idea for someone in your situation. Here is what our Arrowroot record says about it on its own.

Arrowroot: dosing

There is no official or standardized medicinal dose for arrowroot. In cooking, it is used in small amounts as a thickener, and there is no established "therapeutic" dose proven to treat any condition.If you are using a packaged arrowroot product or supplement, follow the directions on the label.

From our Arrowroot monograph — the full record covers uses, side effects and every documented interaction.

Read the full Arrowroot monograph & all interactions
Medication

About Memantine

What Is Memantine Used For?

Brand name: Ebixa

Memantine treats moderate to severe dementia of the Alzheimer's type. It is available as tablets, extended-release capsules, and an oral solution — all approved for this same use.

It does not cure Alzheimer's disease and is not shown to prevent or slow the underlying loss of brain cells. It is used to help manage symptoms of moderate to severe disease.

See full Memantine drug information
Keep checking

Other Drugs & Arrowroot

Browse every other medication we’ve checked against Arrowroot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Arrowroot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Arrowroot list.

See the full Arrowroot interactions page
See every supplement checked against Memantine, ranked by severity
Evidence & sources

Arrowroot References

The 2 references that drive our Arrowroot monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Cooke, C., Carr, I., Abrams, K., and Mayberry, J. Arrowroot as a treatment for diarrhoea in irritable bowel syndrome patients: a pilot study. Arq Gastroenterol. 2000;37(1):20-24. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Arrowroot and Memantine Together: Common Questions

Is it safe to take Arrowroot with Memantine?
We do not list a known interaction between Arrowroot and Memantine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Arrowroot and Memantine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Memantine interact with any supplements?
Yes. Memantine has documented interactions with 18 supplements in our database — Arrowroot is not one of them. The Memantine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Arrowroot monograph Uses, safety profile, and every drug interaction in one place Memantine drug information The full plain-English guide to this medication Memantine supplement interactions Every supplement checked against Memantine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Memantine and Arrowroot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.