Drug & supplement interaction

Ascorbigen + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin

Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin brand name: Lanorinal.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Ascorbigen and Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ascorbigen and Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin and Ascorbigen in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ascorbigen at all — not against Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ascorbigen safety at a glance

Ascorbigen overall Not established There is very little human safety data on ascorbigen as a supplement.
Pregnancy Avoid Safety has not been studied in pregnancy, so it is best to avoid it.
Breastfeeding Avoid No safety data exist for breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin and Ascorbigen? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Ascorbigen and Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas Additional detail

    Ascorbigen

    “Orally, when used in combination with broccoli powder, ascorbigen has been reported to cause flatulence, abdominal distension, and unpleasant after taste. It is unclear if these effects are due to ascorbigen, broccoli powder, or the combination.”

    Ascorbigen · Natural Medicines adverse-effect record, reported in flatulence.

    1 source cited
    1. 15460. Bramwell B, Ferguson S, Scarlett N, Macintosh A. The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial. Altern Med Rev 2000;5:455-62.

    Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin

    Listed in the ADVERSE REACTIONS section of the FDA label for Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin. Read the label on DailyMed ›

Effects for Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin come from the ADVERSE REACTIONS section of its FDA label; effects for Ascorbigen come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin

This page covers Ascorbigen only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin page lists 347 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Ephedra (major).

By severity: 13 major · 285 moderate · 49 minor.

From our pharmacist’s overview on the Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin page

“Lanorinal packs four drugs into one tablet (aspirin, caffeine, a barbiturate, and phenacetin), which is why its interaction list runs to 347 supplement ingredients and deserves genuine respect, with 13 rated major. The aspirin dominates the danger: over 200 of these ingredients can add to its blood-thinning effect and raise bleeding ri…”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interaction page

One more smart check

Taking Ascorbigen as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Ascorbigen, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ascorbigen. Even though Ascorbigen itself has no known interaction with Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ascorbigen and Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ascorbigen
Steady interest

#1,425 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin
Top half

#983 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ascorbigen reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Ascorbigen and Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ascorbigen

What is Ascorbigen?

Ascorbigen
  • Antioxidant support
  • Immune support
  • Fibromyalgia symptoms
  • General wellness
  • Detoxification support

Ascorbigen is a natural compound formed when indole-3-carbinol (from cruciferous vegetables) combines with vitamin C, and it is mainly studied in the lab and in early research. There is not enough good human evidence to confirm it helps any specific health condition, and its safety as a supplement is not well established. Talk with your pharmacist or doctor before taking it.

Derived from cruciferous vegetables (such as cabbage, broccoli, Brussels sprouts) · Capsules, tablets, found naturally in cruciferous vegetables and some combination supplements

An interaction check asks whether these two react with each other — it does not ask whether Ascorbigen is a good idea for someone in your situation. Here is what our Ascorbigen record says about it on its own.

Ascorbigen: dosing

There is no established standard dose for ascorbigen. It has not been studied enough in humans to know a safe and effective amount.If you choose to use a product that contains ascorbigen, follow the directions on the label and do not exceed the recommended amount.

From our Ascorbigen monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ascorbigen monograph & all interactions
Medication

About Aspirin, Butalbital, and Caffeine

What Is Aspirin, Butalbital, and Caffeine Used For?

Brand name: Lanorinal

This combination is used to relieve the symptoms of tension (or muscle contraction) headache. The supported product is the oral capsule.

There is no evidence that it works or is safe for multiple recurrent headaches. Caution is needed because butalbital is habit-forming and can be abused.

See full Aspirin, Butalbital, and Caffeine drug information
Keep checking

Other Drugs & Ascorbigen

Browse every other medication we’ve checked against Ascorbigen — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ascorbigen against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ascorbigen list.

See the full Ascorbigen interactions page
See every supplement checked against Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin, ranked by severity
Evidence & sources

Ascorbigen References

The 1 references that drive our Ascorbigen monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bramwell B, Ferguson S, Scarlett N, Macintosh A. The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial. Altern Med Rev 2000;5:455-62.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ascorbigen and Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin Together: Common Questions

Is it safe to take Ascorbigen with Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin?
We do not list a known interaction between Ascorbigen and Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ascorbigen and Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interact with any supplements?
Yes. Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin has documented interactions with 347 supplements in our database — Ascorbigen is not one of them. The Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ascorbigen monograph Uses, safety profile, and every drug interaction in one place Aspirin, Butalbital, and Caffeine drug information The full plain-English guide to this medication Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin supplement interactions Every supplement checked against Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin and Ascorbigen?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.