Drug & supplement interaction

Astragalus + Uridine Triacetate

Uridine Triacetate brand names: Xuriden, Vistogard.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Astragalus and Uridine Triacetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Uridine Triacetate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Astragalus and Uridine Triacetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Uridine Triacetate and Astragalus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Astragalus safety at a glance

Astragalus overall Use caution Generally well tolerated short-term in healthy adults, but quality human safety data is limited.
Pregnancy Avoid Not enough reliable safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough reliable safety data, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Uridine Triacetate and Astragalus? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Uridine Triacetate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Uridine Triacetate is filed under a single classification — oral drugs. Astragalus has documented interactions with 4 drug classes — the most serious being antidiabetes drugs (moderate), cyclophosphamide (moderate) and immunosuppressants (moderate) — and none of Uridine Triacetate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Astragalus Does Interact With Other Medications

Astragalus has 208 moderate known drug interactions in our database — Uridine Triacetate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 208 No known interaction 2,622 (incl. Uridine Triacetate)
Taking anything else?

Check Another of Your Medications Against Astragalus

Covers the 2,830 medications we’ve checked against Astragalus. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Astragalus and Uridine Triacetate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea reported in 8.7% of FDA reports for Uridine Triacetate Additional detail

    Astragalus

    “Orally, astragalus has reportedly been associated with enterocolitis and nausea in one clinical trial. However, these effects may not have been caused by astragalus.”

    Astragalus · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 17355. Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.

    Uridine Triacetate

    Listed in the ADVERSE REACTIONS section of the FDA label for Uridine Triacetate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Astragalus but not commonly for Uridine Triacetate: muscle pain, heart failure, a fast or pounding heartbeat and sore throat.

Effects for Uridine Triacetate come from the ADVERSE REACTIONS section of its FDA label; effects for Astragalus come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 138 voluntary FDA FAERS reports for Uridine Triacetate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Uridine Triacetate Products Have a Food Rule — Astragalus Should Not Break It

At least one FDA label for a product containing Uridine Triacetate says to take it with food. If you take Astragalus on an empty stomach out of habit, keep them separate — and take Uridine Triacetate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Uridine Triacetate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Administer the dose with food (applesauce, pudding or yogurt) or in milk or infant formula.

From the Dosage and Administration section of the FDA label we read for Uridine Triacetate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Astragalus or Uridine Triacetate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Astragalus or Uridine Triacetate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Uridine Triacetate

This page covers Astragalus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Uridine Triacetate page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Uridine Triacetate page

“Uridine triacetate is a drug you take when absorption truly cannot fail, whether as Vistogard, the emergency antidote for fluorouracil or capecitabine overdose, or as Xuriden for hereditary orotic aciduria. That is why the 17 supplement interactions on file deserve real care rather than a shrug.”

Reviewed by 2 · Jul 18, 2026

Open the Uridine Triacetate interaction page

One more smart check

Taking Astragalus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,437 real supplement products containing Astragalus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Astragalus. Even though Astragalus itself has no known interaction with Uridine Triacetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Astragalus and Uridine Triacetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Astragalus
Top 5%

#72 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Uridine Triacetate
Steady interest

#2,726 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Astragalus reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Astragalus and Uridine Triacetate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Astragalus

What is Astragalus?

Astragalus
  • Immune support
  • Colds and flu
  • Upper respiratory infections
  • Fatigue and stress (adaptogen)
  • Heart health
  • General wellness in traditional medicine

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong human evidence for most uses is still lacking. It is generally well tolerated by healthy adults for short-term use, but should be avoided during pregnancy and breastfeeding due to limited safety data.

Astragalus membranaceus · Fabaceae · Root · Capsules, tablets, dried root, tea, liquid extract (tincture), powder, and injectable forms used in some countries

An interaction check asks whether these two react with each other — it does not ask whether Astragalus is a good idea for someone in your situation. Here is what our Astragalus record says about it on its own.

Astragalus: dosing

There is no official, standardized dose of astragalus. The right amount can depend on the form (capsule, tea, extract), the part of the plant used, and how the product is prepared.Because doses vary widely between products and studies, the best advice is to follow the directions on the product label and not exceed them. A pharmacist can help you review a specific product and decide whether it is appropriate for you.If you start astragalus and notice any unwanted effects, stop and check with a healthcare professional. Avoid using it long-term without medical supervision, since long-term safety is not well established.

From our Astragalus monograph — the full record covers uses, side effects and every documented interaction.

Read the full Astragalus monograph & all interactions
Medication

About Uridine Triacetate

What Is Uridine Triacetate Used For?

Brand names: Xuriden, Vistogard

Uridine triacetate is available as two different products for two distinct uses. Vistogard is used for emergency treatment after an overdose of the chemotherapy drugs fluorouracil or capecitabine — or when someone develops severe, early, or life-threatening side effects from those drugs (such as heart or nervous system problems, severe digestive reactions, or a dangerous drop in white blood cells) within 96 hours of their last dose.

Xuriden is used to treat hereditary orotic aciduria, a rare inherited condition in which the body cannot make enough of a building block called uridine, causing a buildup of orotic acid and problems with blood cell production and other body functions. Both products are approved for adults and children.

See full Uridine Triacetate drug information
Keep checking

Other Drugs & Astragalus

Browse every other medication we’ve checked against Astragalus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
0Minor
2,621No known interaction
208 Moderate 2,621 No interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Astragalus page.

No interaction 2,621 drugs checked — show the list

We also checked Astragalus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,621 medications checked with no known interaction — see the full Astragalus list.

See the full Astragalus interactions page
See every supplement checked against Uridine Triacetate, ranked by severity
Evidence & sources

Astragalus References

The 13 references that drive our Astragalus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.
  2. Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90.
  3. Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9.
  4. Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37..
  5. Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23.
  6. Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.
  7. Zhang, J. G., Yang, N., He, H., Wei, G. H., Gao, D. S., Wang, X. L., Wang, X. Z., and Song, G. Y. [Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure.]. Chin J Integr.Med 2005;11(3):18 PubMed
  8. Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest PubMed
  9. Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. PubMed
  10. Hong KF, Liu PY, Zhang W, Gui DK, Xu YH. The Efficacy and Safety of Astragalus as an Adjuvant Treatment for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. J Integr Complement Med 2023. PubMed
  11. Chan KW, Kwong ASK, Tsui PN, et al. Add-on astragalus in type 2 diabetes and chronic kidney disease: A multi-center, assessor-blind, randomized controlled trial. Phytomedicine 2024;130:155457. PubMed
  12. Han X, Yu T, Chen X, Du Z, Yu M, Xiong J. Effect of Astragalus membranaceus on left ventricular remodeling in HFrEF: a systematic review and meta-analysis. Front Pharmacol 2024;15:1345797. PubMed
  13. Jing P, Hongzheng H, Zhenqi WU, Meijuan Z, Zuojing LI, Gang C. Long-term efficacy and safety of Huangqi ()-based Traditional Chinese Medicine in diabetic peripheral neuropathy: a Meta-analysis of randomized controlled trials. J Tradit Chin Med 2024;44(2):

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Astragalus and Uridine Triacetate Together: Common Questions

Is it safe to take Astragalus with Uridine Triacetate?
We do not list a known interaction between Astragalus and Uridine Triacetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Astragalus and Uridine Triacetate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Astragalus and Uridine Triacetate at the same time of day?
At least one FDA label for a product containing Uridine Triacetate says to take it with food. If you take Astragalus on an empty stomach out of habit, keep them separate and take Uridine Triacetate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Uridine Triacetate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Astragalus and Uridine Triacetate combination checked?
Interactions in our licensed database are recorded against drug classes. Uridine Triacetate is filed under 1 classification, and Astragalus has documented interactions with 4 drug classes — none of Uridine Triacetate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Astragalus interact with any other medications?
Yes. Astragalus has 208 documented drug interactions in our database — Uridine Triacetate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Uridine Triacetate interact with any supplements?
Yes. Uridine Triacetate has documented interactions with 17 supplements in our database — Astragalus is not one of them. The Uridine Triacetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Astragalus monograph Uses, safety profile, and every drug interaction in one place Uridine Triacetate drug information The full plain-English guide to this medication Uridine Triacetate supplement interactions Every supplement checked against Uridine Triacetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 13 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.